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Russian Journal of General Chemistry

, Volume 89, Issue 7, pp 1535–1540 | Cite as

Microwave Assisted Synthesis and Antimicrobial Activity of Novel 1,3,4-Thiadiazoles and 1,2,4-Triazoles Derived from 2-(3-Fluorophenyl)-4-methylthiazole-5-carbohydrazide

  • S. G. Dengale
  • B. K. Karale
  • H. N. Akolkar
  • N. R. Darekar
  • K. K. DeshmukhEmail author
Article
  • 2 Downloads

Abstract

The precursors 2-{[2-(3-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]carbonyl}-N-phenylhydrazinecarbothioamides are synthesized from 2-(3-fluorophenyl)-4-methylthiazole-5-carbohydrazide and aryl isothiocyanates. MW irradiation of the precursors under alkali or acidic conditions led to the products of cyclization 5-[2-(3-fluorophenyl)-4-methylthiazol-5-yl]-N-phenyl-1,3,4-thiadiazol-2-amine or 5-[2-(3-fluorophenyl)-4-methylthiazol-5-yl]-4-phenyl-4H-1,2,4-triazole-3-triiol, accordingly. Structures of the synthesized compounds are confirmed by IR, 1H, and 13C NMR, and mass spectra. All products are tested in vitro for their antibacterial and antifungal activity.

Keywords

thiazole 1,3,4-thiadiazole 1,2,4-triazole antimicrobial activity 

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Notes

Acknowledgments

Authors are thankful to Department of Science and Technology, New Delhi for providing research facilities through FIST scheme and SAIF, Panjab University, Chandigarh for providing spectral facilities.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • S. G. Dengale
    • 1
  • B. K. Karale
    • 2
  • H. N. Akolkar
    • 2
  • N. R. Darekar
    • 2
  • K. K. Deshmukh
    • 1
    Email author
  1. 1.P.G. and Research, Department of Chemistry, Sangamner Nagarpalika ArtsD. J. Malpani Commerce and B.N. Sarada Science CollegeSangamnerIndia
  2. 2.P.G. and Research, Department of ChemistryRadhabai Kale Mahila MahavidyalayaAhmednagarIndia

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