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Russian Journal of General Chemistry

, Volume 89, Issue 7, pp 1528–1534 | Cite as

Synthesis of Some New Substituted Thieno[2,3-d]pyrimidine Derivatives as Antimicrobial Agents

  • M. F. El-Shehry
  • H. M. Hosni
  • A. E. AmrEmail author
  • A. A. Ibrahim
  • Ahmed A. Fayed
  • D. H. Elnaggar
Article
  • 2 Downloads

Abstract

A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N-benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized compounds demonstrate potent antibacterial activity with LD50 comparable with the reference drug indomethacin.

Keywords

thiophene moiety thieno[2,3-d]pyrimidines derivatives antimicrobial activity 

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Notes

Acknowledgments

The authors are grateful to the Deanship of Scientific Research, king Saud University for funding through Vice Deanship of Scientific Research Chairs.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • M. F. El-Shehry
    • 1
    • 2
  • H. M. Hosni
    • 1
  • A. E. Amr
    • 3
    • 4
    Email author
  • A. A. Ibrahim
    • 4
  • Ahmed A. Fayed
    • 5
    • 6
  • D. H. Elnaggar
    • 4
  1. 1.Pesticide Chemistry DepartmentNational Research CenterDokki, CairoEgypt
  2. 2.Al-Zahrawy University CollegeKarbalaIraq
  3. 3.Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration and Development Chair (DEDC)King Saud UniversityRiyadhSaudi Arabia
  4. 4.Applied Organic Chemistry DepartmentNational Research CentreDokki, GizaEgypt
  5. 5.Respiratory Therapy Department, College of Medical Rehabilitation SciencesTaibah UniversityMadinah MunawaraSaudi Arabia
  6. 6.National Research CenterCairo, DokkiEgypt

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