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Russian Journal of General Chemistry

, Volume 89, Issue 7, pp 1502–1512 | Cite as

Synthesis and Anticancer Activity of Thiophene-2-carboxamide Derivatives and In Silico Docking Studies

  • K. C. Gulipalli
  • P. Ravula
  • S. Bodige
  • S. Endoori
  • P. K. R. Cherukumalli
  • J. N. Narendra Sharath Chandra
  • N. SeelamEmail author
Article
  • 6 Downloads

Abstract

A novel series of thiophene-2-carboxamide derivatives are designed and synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectra. The synthesized compounds are evaluated for their in vitro cytotoxic activity by MTT assay. Among the tested compounds, the derivative with 4-Cl-phenyl ring exhibits potent inhibitory activity against MCF-7, K562, HepG2, and MDA-MB-231. The molecular docking study performed for the synthesized compounds against PTP1B exhibits essential key interactions.

Keywords

synthesis thiophene-2-carboxamide anticancer molecular docking protein tyrosine phosphatase inhibitor 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • K. C. Gulipalli
    • 1
  • P. Ravula
    • 2
  • S. Bodige
    • 1
  • S. Endoori
    • 1
  • P. K. R. Cherukumalli
    • 1
  • J. N. Narendra Sharath Chandra
    • 3
  • N. Seelam
    • 1
    Email author
  1. 1.Department of ChemistryKoneru Lakshmaiah Education FoundationVaddeswaram, GunturIndia
  2. 2.Department of Pharmaceutical Chemistry, Gurunanak Institutions Technical CampusSchool of PharmacyHyderabadIndia
  3. 3.Department of Pharmaceutical ChemistryGuruktupa Institute of PharmacyMajalgaonIndia

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