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Russian Journal of General Chemistry

, Volume 89, Issue 7, pp 1496–1501 | Cite as

Synthesis, Antibacterial Activity, and Cytotoxicity of Newly Synthesized N-Substituted 5,6-Dimethoxy-1H-indole Derivatives

  • M. Raghavender
  • B. Shankar
  • P. JalapathiEmail author
  • S. Perugu
Article
  • 2 Downloads

Abstract

A series of novel functionalized N-substituted 5, 6-dimethoxy-1H-indole derivatives is synthesized. All products are evaluated for antibacterial activity using rifampicin and ciprofloxacin as standard drugs and identified as the promising compounds for further studies. The products are screened for their anticancer activity against MCF7 cell line (breast cancer cell-line) using MTT assay. Two compounds display a significant activity against MCF7 cell line at a very low concentration. The structure-cytotoxicity relationship is supported by molecular docking studies of the active compounds against 3S7S receptor.

Keywords

indole analogues cytotoxicity antibacterial activity molecular docking studies 

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Notes

Acknowledgments

The author, Raghavender M., thanks to the Central Facilities for Research and Development, Osmania University, Hyderabad, India, for providing analytical support. We also thank to National Institute of Technology, Warangal, Telangana, India for providing facilities of biological activity docking studies.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • M. Raghavender
    • 1
  • B. Shankar
    • 2
  • P. Jalapathi
    • 1
    Email author
  • S. Perugu
    • 3
  1. 1.Department of ChemistryUniversity College of Engineering, Osmania UniversityHyderabadIndia
  2. 2.Department of ChemistryUniversity College of Science, Saifabad, Osmania UniversityHyderabadIndia
  3. 3.Department of BiotechnologyNational Institute of TechnologyWarangalIndia

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