Synthesis, Antibacterial Activity, and Cytotoxicity of Newly Synthesized N-Substituted 5,6-Dimethoxy-1H-indole Derivatives
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A series of novel functionalized N-substituted 5, 6-dimethoxy-1H-indole derivatives is synthesized. All products are evaluated for antibacterial activity using rifampicin and ciprofloxacin as standard drugs and identified as the promising compounds for further studies. The products are screened for their anticancer activity against MCF7 cell line (breast cancer cell-line) using MTT assay. Two compounds display a significant activity against MCF7 cell line at a very low concentration. The structure-cytotoxicity relationship is supported by molecular docking studies of the active compounds against 3S7S receptor.
Keywordsindole analogues cytotoxicity antibacterial activity molecular docking studies
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The author, Raghavender M., thanks to the Central Facilities for Research and Development, Osmania University, Hyderabad, India, for providing analytical support. We also thank to National Institute of Technology, Warangal, Telangana, India for providing facilities of biological activity docking studies.