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Russian Journal of General Chemistry

, Volume 89, Issue 7, pp 1491–1495 | Cite as

Synthesis and Biological Evaluation of Amide Derivatives of Imidazopyridine as Anticancer Agents

  • V. RameshEmail author
  • G. Purna Chander Rao
  • D. Ramachandran
  • A. Kalyan Chakravarthy
Article

Abstract

A series of new amide derivatives of imidazopyridine is synthesized and structures of the products are confirmed by 1H and 13C NMR, and mass spectral data. The synthesized derivatives are screened for their anticancer activity against four human cancer cell lines: lung cancer (A549), breast cancer (MCF-7), melanoma cancer (A375), and colon cancer (HT-29). Six synthesized compounds exhibit more potent activity than the control drug.

Keywords

Nocodazole Celebrex pyrazole and anticancer activity 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • V. Ramesh
    • 1
    Email author
  • G. Purna Chander Rao
    • 1
  • D. Ramachandran
    • 1
  • A. Kalyan Chakravarthy
    • 2
  1. 1.Department of ChemistryAcharya Nagarjuna UniversityGunturIndia
  2. 2.Integrated Product DevelopmentDr. Reddy’s LaboratoriesBachupally, HyderabadIndia

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