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Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amide Oxime Ethers and 2-Iodobenzonitrile

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Abstract

4-Substituted O-benzyl benzamide oximes reacted with 2-iodobenzonitrile in the presence of 0.1 mol % of [Pd2(dba)3], 0.2 mol % of XantPhos, and 1.5 equiv of Cs2CO3 in dioxane under argon to give 2-arylquinazolin-4-amines. The described reaction is a new type of cascade processes, which affords 4-amino-quinazoline derivatives without using highly reactive chlorinating agents.

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Authors and Affiliations

  1. St. Petersburg State University, Universitetskaya nab. 7–9, St. Petersburg, 199034, Russia

    M. Ya. Demakova & R. M. Islamova

  2. Center for X-Ray Diffraction Studies, St. Petersburg State University, St. Petersburg, Russia

    V. V. Suslonov

Authors
  1. M. Ya. Demakova
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  2. R. M. Islamova
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  3. V. V. Suslonov
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Correspondence to M. Ya. Demakova.

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Demakova, M.Y., Islamova, R.M. & Suslonov, V.V. Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amide Oxime Ethers and 2-Iodobenzonitrile. Russ J Gen Chem 89, 668–672 (2019). https://doi.org/10.1134/S1070363219040054

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  • DOI: https://doi.org/10.1134/S1070363219040054

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