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Russian Journal of General Chemistry

, Volume 89, Issue 2, pp 324–329 | Cite as

Synthesis and Anticancer Activity of Amide Derivatives of 1,2-Isoxazole Combined 1,2,4-Thiadiazole

  • S. Shahinshavali
  • R. Sreenivasulu
  • V. R. Guttikonda
  • D. Kolli
  • M. V. B. RaoEmail author
Article
  • 7 Downloads

Abstract

A series of amide derivatives of 1,2-isoxazole combined with 1,2,4-thiadiazole are synthesized 11a–11j. Their chemical structures are confirmed by 1H and 13C NMR, and mass spectra. The products are tested for their anticancer activity against four types of human cancer cell lines, including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian). Etoposide is used as a positive control. Most of the compounds show good anticancer activity. The compounds 11b, 11c, 11d, 11e, 11g, and 11j demonstrate more potent activity than etoposide.

Keywords

Luminespib Cefozopram isoxazole thiadiazole anticancer activity 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • S. Shahinshavali
    • 1
  • R. Sreenivasulu
    • 2
  • V. R. Guttikonda
    • 3
  • D. Kolli
    • 4
  • M. V. B. Rao
    • 1
    Email author
  1. 1.Department of ChemistryKrishna UniversityMachilipatnamIndia
  2. 2.Department of Chemistry, University College of Engineering (Autonomous)Jawaharlal Nehru Technological UniversityKakinadaIndia
  3. 3.Department of ChemistrySRR and CVR Government Degree College (Autonomous)VijayawadIndia
  4. 4.Department of ChemistryKoneru Lakshmaiah Education Foundation, Green FieldsVaddeswaramIndia

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