Russian Journal of General Chemistry

, Volume 89, Issue 2, pp 319–323 | Cite as

Synthesis and Antibacterial Assay of Some New Pyrenyl Pyridine Candidates

  • N. M. KhalifaEmail author
  • M. E. Haiba
  • M. M. Taha
  • M. A. Al-Omar


Novel polycyclic compounds, 1-pyrene-based pyridone derivatives, are synthesized by treatment of pyrenyl acetohydtazide with several arylidenemalononitriles and acetylacetone. Intramolecular cyclization furnishes the functionalized substituted pyridine-2-ones with high yields. Structures of the products are elucidated from the spectral data. Tests on antibacterial activity of the products reveal their high antibacterial effect.


pyrenes 2-pyridone derivatives antibacterial agents synthesis 


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • N. M. Khalifa
    • 1
    • 2
    Email author
  • M. E. Haiba
    • 2
  • M. M. Taha
    • 3
  • M. A. Al-Omar
    • 1
  1. 1.Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of PharmacyKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Therapeutic Chemistry Department, Pharmaceutical and Drug Industries DivisionNational Research CentreGizaEgypt
  3. 3.Department of Chemistry, Faculty of ScienceMenoufia UniversityMenoufiaEgypt

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