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Russian Journal of General Chemistry

, Volume 89, Issue 2, pp 230–235 | Cite as

Pyrazine-2-carbohydrazone of Pyridoxal 5′-Phosphate: Synthesis, Stability, Formation Kinetics, and Interaction with DNA

  • G. A. GamovEmail author
  • M. N. Zavalishin
  • V. V. Aleksandriyskii
  • V. A. Sharnin
Article
  • 7 Downloads

Abstract

(5-Hydroxy-6-methyl-4-{(E)-[2-oxo-2-(pyrazin-2-yl)ethyl]hydrazinylidenemethyl}pyridin-3-yl)- methyl phosphate has been synthesized via the interaction of pyridoxal-5-phosphate and pyrazin-2- carbohydrazide. Its stability constants in an aqueous solution at pH = 1.9, 6.6, 7.0, and 7.4 have been determined. The kinetics of formation and hydrolysis of the hydrazone has been studied, and rate constants of the direct and reverse reactions have been calculated from the electronic absorption spectroscopy data. The interaction of the obtained hydrazone and its Cu(II) complex with calf thymus DNA has been investigated.

Keywords

hydrazone stability constant rate constant pyridoxal-5-phosphate DNA 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • G. A. Gamov
    • 1
    Email author
  • M. N. Zavalishin
    • 1
  • V. V. Aleksandriyskii
    • 1
  • V. A. Sharnin
    • 1
  1. 1.Ivanovo State University of Chemistry and TechnologyIvanovoRussia

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