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Russian Journal of General Chemistry

, Volume 89, Issue 1, pp 160–164 | Cite as

α-Azidoalkylphosphonate in 1,3-Dipolar Cycloaddition with Propargyl-Containing Pharmacophores

  • V. B. SokolovEmail author
  • A. Yu. Aksinenko
  • T. A. Epishina
  • T. V. Goreva
Letters to the Editor
  • 5 Downloads

Abstract

Copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition reactions of α-azidoalkylphosphonates with propargyl-containing pharmacophores such as phenothiazine, tetrahydro-γ-carboline, tetrahydrocarbazole, carbazole and 3,5-dimethyl-1-aminoadamantanes led to the formation of the corresponding 1, 4-substituted 1,2,3-triazoles and make it possible to introduce a diethoxyphosphorylalkyl fragment into the molecules of potential neuroprotectors using a triazole-containing spacer.

Keywords

α-azidoalkylphosphonates phenothiazine carbazole tetrahydrocarbazole tetrahydro-γ-carboline 1,3-dipolar cycloaddition 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • V. B. Sokolov
    • 1
    Email author
  • A. Yu. Aksinenko
    • 1
  • T. A. Epishina
    • 1
  • T. V. Goreva
    • 1
  1. 1.Institute of Physiologically Active Compounds of the Russian Academy of SciencesChernogolovkaRussia

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