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Russian Journal of General Chemistry

, Volume 89, Issue 1, pp 32–36 | Cite as

Synthesis of New Thiazolo[3,2-b][1,2,4]triazole Derivatives and Preliminary Evaluation of Their Biological Activity

  • A. P. YengoyanEmail author
  • V. A. Pivazyan
  • E. A. Chazaryan
  • R. S. Hakobyan
Article
  • 16 Downloads

Abstract

Heterocyclization of 3-[(1H-1,2,4-triazol-3-yl)thio]pentane-2,4-dione afforded 1-(6-methylthiazolo[3,2-b][1,2,4]-triazol-5-yl)ethan-1-one, the reactions of which with hydroxylamine, hydrazincarboxamide, hydrazincarbothioamide, hydrazine hydrate and para-toluenesulfonyl hydrazide resulted in the formation of the corresponding derivatives. 1-(6-Methylthiazolo[3,2-b][1,2,4]triazol-5-yl)ethan-1-one oxime reacted with alkyl halides and phenyl isocyanate to produce the corresponding O-alkyl- and O-phenylcarbamoyl derivatives. The growth regulating activity of the compounds obtained was studied.

Keywords

thiazolo[3,2-b][1,2,4]triazoles 1-(6-methylthiazolo[3,2-b][1,2,4]triazol-5-yl)ethan-1-one oxime heterocyclization growth regulating activity 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. P. Yengoyan
    • 1
    • 2
    Email author
  • V. A. Pivazyan
    • 2
  • E. A. Chazaryan
    • 2
  • R. S. Hakobyan
    • 2
  1. 1.Russian-Armenian UniversityYerevanArmenia
  2. 2.Pesticide Synthesis and Plant Protection LaboratoryNational Agrarian University of ArmeniaYerevanArmenia

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