Russian Journal of General Chemistry

, Volume 88, Issue 13, pp 2982–2989 | Cite as

Results of Examination of the Biological Activity of Nonmedical Antibiotics with a View to Finding Environmentally Friendly Pesticides for Plant Protection

  • V. V. BelakhovEmail author
  • I. V. Boikova
  • I. I. Novikova
  • V. A. Kolodyaznaya


Biological experiments with nonmedical antibiotics lucensomycin, tetramycins A and B, aureofungins A and B, and antimycin A were carried out. These antibiotics were found to be environmentally friendly preparations possessing antifungal, antibacterial, and insecticidal activities. The prospects for their application for plant protection against diseases and harmful arthropods and for increasing the agricultural crop yield were shown.


nonmedical antibiotics biopreparations plant protection antifungal activity antibacterial activity insecticidal activity polyfunctional preparations 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    The Pesticide Manual, MacBean, C., Ed., 16 ed., Hampshire (UK): BCPC (British Crop Production Council), 2012.Google Scholar
  2. 2.
    Antibiotics: Current Innovations and Future Trends, Sanchez, S., and Demain, A.L., Eds., Norfolk (UK): Caister Academic, 2015, p. 113.Google Scholar
  3. 3.
    Basic and Applied Aspects of Biopesticides, Sahayaraj, K., Ed., New Delhi (India): Springer, 2014.Google Scholar
  4. 4.
    McManus, P.S., Stockwell, V.O., Sundin, G.W., and Jones, A.L., Nmau. Rev. Phytopathol., 2002, vol. 40, p. 443.CrossRefGoogle Scholar
  5. 5.
    Kumar, K., Gupta, S.C., Chander, Y., and Singh, A.K., Adv. Agron., 2005, vol. 87, p. 1.CrossRefGoogle Scholar
  6. 6.
    Stockwell, V.O., Duffy, B., Rev. Sci. Tech. (International Office of Epizootics), 2012, vol. 31, no. 1, p. 199.CrossRefGoogle Scholar
  7. 7.
    Chang, Q., Wang, W., Regev-Yochay, G., Lipsitch, M., and Hanage, W.P., Evol. Appl., 2015, vol. 8, no. 3, p. 240.CrossRefGoogle Scholar
  8. 8.
    Hook, D.J., in Basic Biotechnology, Ratledge, C. and Kristiansen, B., Eds., 3 ed., Cambridge (UK): Cambridge Univ. Press, 2006.Google Scholar
  9. 9.
    Corcoran, J.W., Biosynthesis, Berlin: Springer, 2012.Google Scholar
  10. 10.
    Martin, J.-F., Garcia-Estrada, C., and Zeilinger, S., Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, New York: Springer, 2014.CrossRefGoogle Scholar
  11. 11.
    Woods, N., Cowles, G., Crome, J., Lambourne, R., Simpson, P., and Webster, R., Agricultural Chemical User’s Manual, Brisbane (Australia): DPI&F, 2005.Google Scholar
  12. 12.
    Pesticide Chemistry: Crop Protection, Public Health, Environmental Safety, Okawa, H., Mijagawa, H., and Lee, P.W., Eds., Weinheim (Germany): Wiley-VCH, 2007.Google Scholar
  13. 13.
    Nollet, L.M.L. and Rathore, H.S., Biopesticides Handbook, Boca Raton (FL, USA): CRC Press Taylor & Francis Group, 2015.CrossRefGoogle Scholar
  14. 14.
    Biopesticides: State of the Art and Future Opportunities, Gross, A., Coats, J.R., Duke, S.O., and Seiber, J.N., Eds., Washington: American Chemical Society, 2015.Google Scholar
  15. 15.
    Jampilek, J., Expert Opin. Drug Discovery, 2016, vol. 11, no. 1, p. 1.CrossRefGoogle Scholar
  16. 16.
    Egorov, N.S., Osnovy ucheniya ob antibiotikakh (Basic Theory of Antibiotics), Moscow: Mosk. Gos. Univ., 6 ed., 2004, p. 492.Google Scholar
  17. 17.
    Shternshis, M.V., Biologicheskaya zashchita rastenii (Biological Plant Protection), Moscow: KolosS, 2004.Google Scholar
  18. 18.
    Watson, D., Pesticide Management and Insecticide Resistance, New York: Elsevier Science, 2012.Google Scholar
  19. 19.
    Singh, D.K., Pesticide Chemistry and Toxicology, Danvers (MA, USA): Bentham Science, 2012, vol. 1.Google Scholar
  20. 20.
    Dornberger, K., Funger, R., Bradler, G., and Thrum, H., J. Antibiot., 1971, vol. 24, no. 3, p. 172.CrossRefGoogle Scholar
  21. 21.
    Radics, L., Incze, M., Dornberger, K., and Thrum, H., Tetrahedron, 1982, vol. 38, no. 1, p. 183.CrossRefGoogle Scholar
  22. 22.
    Zhong, L.-J., Zhao, X.-H., Zhang, Q.-H., Xu, C., and Zhu, H.-L., Plant Dis. Pests, 2010, vol. 1, no. 3, p. 6.Google Scholar
  23. 23.
    Shentu, X.-P., Li, D.-T., Xu, J.-F., She, L., and Yu, X.-P., Pestic. Biochem. Physiol., 2016, vol. 128, p. 16.CrossRefGoogle Scholar
  24. 24.
    Thirumalachar, M.J., Rahalkar, P.W., Sukapure, R.S., Gopalkrishnan, K.S., Hindustan Antibiot. Bull., 1964, vol. 6, no. 3, p. 108.Google Scholar
  25. 25.
    Bhate, D.S. and Acharya, S.P., Hindustan Antibiot. Bull., 1964, vol. 6, no. 4, p. 170.Google Scholar
  26. 26.
    Misato, T. and Yoneyama, K., in Advances in Agricultural Microbiology, Subba Rao, N.S., Ed., New Delhi (India): Butterworth & Co, 1982, chapter 18, p. 465.Google Scholar
  27. 27.
    Sukapure, R.S., Rahalkar, P.W., and Gharpure, Y.H., in Antimicrobials and Agriculture, Proc. 4 Int. Symp. on Antibiotics in Agriculture: Benefits and Malefits, Woodbine, M., Ed., London: Butterworth, 1984, p. 137.Google Scholar
  28. 28.
    Coicoechea, N., Pest Manag. Sci., 2009, vol. 65, no. 8, p. 831.CrossRefGoogle Scholar
  29. 29.
    Ulrich, E.M., Morrison, C.N., Goldsmith, M.R., and Foreman, W.T., Rev. Environ. Contam. Toxicol., 2012, vol. 217, p. 1.Google Scholar
  30. 30.
    Graessle, O.E., Phares, H.F., and Robinson, H.J., Antibiot. Chemother., 1962, vol. 12, no. 10, p. 608.Google Scholar
  31. 31.
    Manwaring, D.G., Rickards, R.W., Gaudiano, G., and Nicolella, V., J. Antibiot., 1969, vol. 22, no. 11, p. 545.CrossRefGoogle Scholar
  32. 32.
    Pandey, R.C. and Rinehart, K.L., J. Antibiot., 1976, vol. 29, no. 10, p. 1035.CrossRefGoogle Scholar
  33. 33.
    Kotler-Brajtburg, J., Medoff, G., Kobayashi, G.S., Boggs, S., Schlessinger, D., Pandey, R.C., and Rinehart, K.L., Antimicrob. Agents Chemother., 1979, vol. 15, no. 5, p. 716.CrossRefGoogle Scholar
  34. 34.
    Van Rijn, F.T.J., Tan, H.S., and Warmerdam, M.J.M., Eur. Patent 608944, Chem. Abstr., 1994, vol. 121, no. 17816.Google Scholar
  35. 35.
    Kuskov, A.N., Goryachaya, A.V., Artyukhov, A.A., and Shtil’man, M.I., RF Patent 2432741, Chem. Abstr., 2011, vol. 155, no. 608293.Google Scholar
  36. 36.
    Leben, C. and Keitt, G.W., Phytopathology, 1948, vol. 38, p. 899.Google Scholar
  37. 37.
    Leben, C. and Keitt, G.W., Phytopathology, 1949, vol. 39, p. 529.Google Scholar
  38. 38.
    Dunshee, B.R., Leben, C., Keitt, G.W., and Strong, F.M., J. Am. Chem. Soc., 1949, vol. 71, no. 7, p. 2436.CrossRefGoogle Scholar
  39. 39.
    Lockwood, J.L., Leben, C., and Keitt, G.W., Phytopathology, 1954, vol. 44, p. 438.Google Scholar
  40. 40.
    Rieske, J.S., in Antibiotics: Mechanism of Action, Gottlieb, D. and Shaw, P.D., Eds., New York: Springer, 1967, vol. 1, p. 542–584.Google Scholar
  41. 41.
    Vezina, C., Pure Appl. Chem., 1971, vol. 28, no. 4, p. 681.CrossRefGoogle Scholar
  42. 42.
    Arcamone, F.-M., Chemistry–Eur. J., 2009, vol. 15, no. 32, p. 7774.CrossRefGoogle Scholar
  43. 43.
    Zhang, N., Song, Z., Xie, Y., Cui, P., Jiang, H., Yang, T., Ju, R., Zhao, Y., Li, J., and Liu, X., World J. Microbiol. Biotechnol., 2013, vol. 29, no. 8, p. 1443.CrossRefGoogle Scholar
  44. 44.
    Song, Y., He, L., Chen, L., Ren, Y., Lu, H., Geng, S., Mu, W., and Liu, F., Eur. J. Plant Pathol., 2016, vol. 146, no. 2, p. 337.CrossRefGoogle Scholar
  45. 45.
    Thomas, A.H. and Newland, P., J. Chromatogr., 1986, vol. 354, p. 317.CrossRefGoogle Scholar
  46. 46.
    Komori, T. and Morimoto, Y., J. Chromatogr., 1989, vol. 481, p. 416.CrossRefGoogle Scholar
  47. 47.
    Raatikainen, O., J. Chromatogr., 1991, vol. 588, p. 356.CrossRefGoogle Scholar
  48. 48.
    Pimenova, M.N., Grechushkina, N.N., Azova, L.G., Netrusov, A.I., Semenova, E.V., Zakharchuk, L.M., Zinchenko, V.V., Kolotilova, N.N., Myl’nikova, S.I., Nefelova, M.V., and Botvinko, I.V., Rukovodstvo k prakticheskim zanyatiyam po mikrobiologii (Guide to Practical Training in Microbiology), Moscow: Mosk. Gos. Univ., 1995.Google Scholar
  49. 49.
    Mobius, D., Miller, R., and Fainerman, V.B., Surfactants: Chemistry, Interfacial Properties, Applications, 1st ed., Amsterdam: Elsevier Science, vol. 13, 2001.Google Scholar
  50. 50.
    TU (Technical Specifications) 2483-077-05766801-98: Neonols.Google Scholar
  51. 51.
    RF Patent 2160311, Byull. Izobret. Polez. Mod., no. 2, 2001.Google Scholar
  52. 52.
    RF Patent 2314691, Byull. Izobret. Polez. Mod., no. 5, 2008.Google Scholar
  53. 53.
    Franklin, T.J. and Snow, G.A., Biochemistry of Antimicrobial Action, Cambridge (UK): Chapman and Hall, 1981, p. 145–147.Google Scholar
  54. 54.
    Egorov, N.S., Osnovy ucheniya ob antibiotikakh (Fundamentals of the Theory of Antibiotics), Moscow: Mosk. Gos. Univ., 5 ed., 1994, p. 441.Google Scholar
  55. 55.
    Derse, P.H. and Strong, F.M., Nature, 1963, vol. 200, p. 600.CrossRefGoogle Scholar
  56. 56.
    Lennon, R. and Vezina, C., Adv. Appl. Microbiol., 1973, vol. 16, p. 55.CrossRefGoogle Scholar
  57. 57.
    Kido, G.S. and Spyhalski, E., Science, 1950, vol. 112, no. 2902, p. 172.CrossRefGoogle Scholar
  58. 58.
    Song, C. and Scharf, M.E., Pest Manag. Sci., 2008, vol. 65, no. 6, p. 697.CrossRefGoogle Scholar
  59. 59.
    Yamac, M., Sahin, E., Ceyhan, E., Amoroso, M.J., Cuozzo, S.A., and Pilatin, S., Fresenius Environ. Bull., 2010, vol. 19, no. 5, p. 862.Google Scholar
  60. 60.
    Tokhtamuratov, E., Silaev, A.B., and Askarova, S.A., Uzbek. Biol. Zh., 1973, vol. 17, no. 1, p. 49.Google Scholar
  61. 61.
    Khodzhibaeva, S.M., Borodin, G.I., and Askarova, S.A., Sel’skokhoz. Biol., 1973, vol. 8, no. 3, p. 431.Google Scholar
  62. 62.
    Belakhov, V.V. and Smirnova, G.K., in Materialy nauchno-prakticheskoi konferentsii Vsesoyuznogo naucho-issledovatel’skogo tekhnologicheskogo instituta antibiotikov i fermentov meditsinskogo naznacheniya (VNITIAF) [Proc. Sci.-Practical Conf. of the All-Union Research Technological Institute of Antibiotics and Medical Enzymes (VNITIAF)], Leningrad: VNITIAF, 1988, p. 93.Google Scholar
  63. 63.
    Belakhov, V.V., Vlasenko, A.Yu., Levina, A.A., Shenin, Yu.D., Rozhkova, N.G., and Smirnova, G.K., Antibiot. Khimioter., 1991, vol. 36, no. 9, p. 11.Google Scholar
  64. 64.
    Balashova, N.N. and Babak, N.M., in Trudy Moldavskogo nauchno-issledovatel’skogo instituta oroshaemogo zemledeliya i ovoshchevodstva (MNIIOZO) [Proc. the Moldavian Scientific Research Institute of Irrigated Agriculture and Vegetable Growing (MNIIOZO)], 1964, Chisinau, MNIIOZ, vol. IV, issue 1, p. 200.Google Scholar
  65. 65.
    Molotkova, N.D., Mikol. Fitopatol., 1967, vol. 1, no. 1, p. 90.Google Scholar
  66. 66.
    Molotkova, N.D., in Nauchnye trudy Leningradskoi lesotekhnicheskoi akademii (LLTA) [Scientific Works of the Leningrad Forestry Academy (LLTA)], Leningrad, 1968, vol. 110, p. 172.Google Scholar
  67. 67.
    D’yakova, T.I. and Dement’eva, M.I., in Itogi eksperimental’nykh rabot molodykh issledovatelei po voprosam sel’skogo khozyaistva: Trudy Moskovskogo gosudarstvennogo universiteta (MGU) [Results of the Experimental Work of Young Researchers on Agriculture Issues: Proc. Moscow State University (MSU)], Moscow: Mosk. Gos. Univ., 1970, issue 17, p. 160.Google Scholar
  68. 68.
    Cidaria, D., Andriollo, N., Cassani, G., Crestani, E, Spera, S., Garavaglia, C., Pirali, G., and Confalonieri, G., US Patent 5126265, Chem. Abstr., 1990, vol. 113, no. 210128.Google Scholar
  69. 69.
    Scacchi, A., Andriollo, N., and Cassani, G., Pesticide Science, 1995, vol. 45, no. 1, p. 49.CrossRefGoogle Scholar
  70. 70.
    Sobiech, L., Szczeblewski, P., Kosiada, T., Sawinska Z., Skrzypczak, G., and Borowski, E., Przem. Chem., vol. 95, no. 5, p. 928.Google Scholar
  71. 71.
    Borowski, E., Salewska, N., Boros-Majewska, J., Milewska, M., Wysocka, M., Milewski, S., Skladanowski, A., Treder, A., Sadowska, E., and Chabowska, I., US Patent 9447136, Chem. Abstr., 2013, vol. 159, no. 478986.Google Scholar
  72. 72.
    Coqueron, P.-Y., Grosjean-Cournoyer, M.-C., Hutin, P., Voerste, A., and Wachendorff-Neumnma, U., US Patent 9060518, Chem. Abstr., 2013, vol. 167, no. 96596.Google Scholar
  73. 73.
    Carlile, W.R., Control of Crop Diseases, 3rd ed., Cambridge: Cambridge Univ. Press, 2012.CrossRefGoogle Scholar
  74. 74.
    Sokirko, V.P., Gor’kovenko, V.S., and Zazimko, M.I., Fitopatogennye griby (morfologiya i sistematika) [Phytopathogenic Fungi (Morphology and Systematics)], Krasnodar: Kuban. Gos. Agrar. Univ., 2014.Google Scholar
  75. 75.
    Matthews, G.A., Bateman, R., and Miller, P., Pesticide Application Methods, 4th ed., New York: Wiley, 2014.CrossRefGoogle Scholar
  76. 76.
    Reddy, P. Parvatha, Recent Advances in Crop Protection, 1st ed., New Delhi: Springer, 2013.CrossRefGoogle Scholar
  77. 77.
    Oliver, R. and Oliver, R.P., Fungicides in Crop Protection, 2nd ed., Oxfordshire (UK): CABI, 2014.CrossRefGoogle Scholar
  78. 78.
    Insecticides: Occurrence, Global Threats and Ecological Impact, Montgomery, J., Ed., New York: Nova Science, 2015.Google Scholar
  79. 79.
    Gannibal, F.B., in Laboratoriya mikologii i fitopatologii im. A.A.Yachevskogo Vsesoyuznogo instituta zashchity rastenii. Istoriya i sovremennost’ (Yachevskii Laboratory of Mycology and Phytopathology, All-Russian Institute of Plant Protection: History and Modernity), Dmitriev, A.P., Ed., St. Petersburg: Vses. Inst. Zashchity Rastenii, 2007, p. 82.Google Scholar
  80. 80.
    Kolkhir, P.V., Dokazatel’naya allergologiya-immunologiya (Evidence-Based Allergology-Immunology), Moscow: Prakticheskaya Meditsina, 2010, p. 45.Google Scholar
  81. 81.
    Gagkaeva, T.Yu., Mikol. Fitopatol., 2009, vol. 43, no. 4, p. 331.Google Scholar
  82. 82.
    Summerell, B.A., Laurence, M.H., Liew, E.C.Y., and Leslie, J.F., Fungal Divers., 2010, vol. 44, no. 1, p. 3.CrossRefGoogle Scholar
  83. 83.
    Fusarium: Genomics, Molecular and Cellular Biology, Brown, D.W. and Proctor, R.H., Eds., Norfolk (United Kingdom): Caister Academic, 2013.Google Scholar
  84. 84.
    Fusarium: Epidemiology, Environmental Sources and Prevention (Botanical Research and Practices), Rios, T.F. and Ortega, E.R., Eds., 1st ed., New York: Nova Sciences, 2012Google Scholar
  85. 85.
    Gibb, T.J. and Oseto, C., Arthropod Collection and Identification: Laboratory and Field Techniques, New York: Academic, 2005.Google Scholar
  86. 86.
    Economic and Ecological Significance of Arthropods in Diversified Ecosystems: Sustaining Regulatory Mechanisms, Chakravarthy, A.K. and Sridhara, S., Eds., Singapore: Springer, 2016.Google Scholar

Copyright information

© Pleiades Publishing, Ltd 2019

Authors and Affiliations

  • V. V. Belakhov
    • 1
    Email author
  • I. V. Boikova
    • 2
  • I. I. Novikova
    • 2
  • V. A. Kolodyaznaya
    • 3
  1. 1.Schulich Faculty of ChemistryTechnion – Israel Institute of TechnologyHaifaIsrael
  2. 2.Microbiological Plant Protection LaboratoryAll-Russian Institute of Plant ProtectionSt. PetersburgRussia
  3. 3.Department of BiotechnologySt. Petersburg State Chemical-Pharmaceutical UniversitySt. PetersburgRussia

Personalised recommendations