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Russian Journal of General Chemistry

, Volume 88, Issue 11, pp 2410–2419 | Cite as

Synthesis, Antioxidant, and Antimicrobial Activities of Novel Bis-Aroylbenzofuran Fused 1,2,3-Triazoles Bearing Alkane Spacers

  • K. Kiran
  • M. SarasijaEmail author
  • B. A. Rao
  • A. Jeyanthi
  • A. S. Rao
  • D. Ashok
Article
  • 7 Downloads

Abstract

A series of novel fused bis-aroylbenzodifuran derivatives linked via bis-1,2,3-triazole moiety containing alkane spacers 15, 19a–19d are synthesized in 68–80% yields by the Huisgen cycloaddition (Click) reaction of alkane azides 4–8 with acetylene intermediate 3 followed by cyclization of the corresponding bishydroxyacetophenone derivatives 9–13 with various p-substituted phenacyl bromides 14a–14d. The isolated compounds are characterized by IR, NMR and mass spectral data. The title compounds are screened in vitro for their antimicrobial and antioxidant activities. The results of the studies indicate antimicrobial activity of compounds 16a and 16b compared to that of the standard Streptomycin. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity test of the synthesized compounds indicates the compounds 15d and 16d as highly active as compared to the standard 2,6-bis(1,1-dimethylethyl)-4-methylphenol (BHT).

Keywords

bis-1,2,3-triazole bis-aroylbenzodifuran Click reaction antimicrobial and antioxidant activity 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • K. Kiran
    • 1
    • 2
  • M. Sarasija
    • 3
    Email author
  • B. A. Rao
    • 4
  • A. Jeyanthi
    • 3
  • A. S. Rao
    • 5
  • D. Ashok
    • 4
  1. 1.Department of ChemistryJawaharlal Nehru Technological University, HyderabadTelanganaIndia
  2. 2.Integrum Life Sciences Private Limited, Plot no. 34, ALEAP Industrial Estate, Pragathi Nagar, Gajularamaram, Quthubullapur Mandal, Medchal DistrictTelanganaIndia
  3. 3.Department of ChemistrySatavahana University, KarimnagarTelanganaIndia
  4. 4.Green and Medicinal Chemistry Laboratory, Department of ChemistryOsmania University, HyderabadTelanganaIndia
  5. 5.Vagdevi Innoscience Pvt.Ltd, Nacharam, HyderabadTelanganaIndia

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