Russian Journal of General Chemistry

, Volume 88, Issue 10, pp 2183–2189 | Cite as

Design, Synthesis, and Anticancer Evaluation of Tetrazole-Fused Benzoxazole Derivatives as Tubulin Binding Agents

  • P. RavikumarEmail author
  • G. S. B. Raolji
  • K. Venkata Sastry
  • S. Kalidasu
  • T. Balaaraju


A novel series of tetrazole fused benzoxazole derivatives 9a9j are synthesized, and their structures are characterized by 1H and 13C NMR, and mass spectra. The compounds 9a, 9b, 9g, 9h, and 9j demonstrate the highest activity. The compounds 9b and 9g exhibit good anticancer activity, in particular against MCF7, Hop62, and A-549 cell lines with the range of GI50 values from <0.1 to 4.56 μM. Molecular docking study is carried out for the compounds 9a9j, according to which the compound 9b forms one hydrogen bond with THR766 with the highest docking score (–7.33). This indicates that 9b is effeciently binging to tubulin site.


tetraxole benzoxazole cephalosporin anticancer activity molecular docking 


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • P. Ravikumar
    • 1
    • 2
    Email author
  • G. S. B. Raolji
    • 2
  • K. Venkata Sastry
    • 3
  • S. Kalidasu
    • 1
    • 2
  • T. Balaaraju
    • 4
  1. 1.Department of ChemistryJNT UniversityHyderabadIndia
  2. 2.GVK Biosciences Private Limited, Nacharam, IDA MallapurHyderabadIndia
  3. 3.CMR College of Pharmacy, MedchalHyderabadIndia
  4. 4.Department of Chemistry, School of ScienceGitam UniversityHyderabadIndia

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