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Russian Journal of General Chemistry

, Volume 88, Issue 10, pp 2154–2162 | Cite as

Synthesis, Characterization, Computational, Antimicrobial Screening, and MTT Assay of Thiazolidinone Derivatives Containing the Indole and Pyridine Moieties

  • M. Arshad
  • M. Shoeb Khan
  • S. A. Asghar Nami
  • D. Ahmad
Article
  • 14 Downloads

Abstract

A series of novel 2-{[1-(arenesulfonyl)-1H-indol-3-yl]-4-oxo-1,3-thiazolidin-3-yl}pyridine-4-carboxamide derivatives was designed and calculate for their computational properties like physicochemical parameters and bioactivity score. Bioactive compounds 1–8, were then synthesized, Characterized by various spercoscopic techniques and assessed for antibacterial activity against S. aureus, S. epidermidis, P. mirabilis, and E. coli. The percent viability of the cells was carried out by MTT assay using HepG2 cells. The results for antibacterial activity were observed in strong recommendation with the computation results. The synthesized compounds were found to portray better activity and lower cytotoxicity when compared to the standard drug Ciprofloxacin.

Keywords

2-{[1-(arenesulfonyl)-1H-indol-3-yl]-4-oxo-1,3-thiazolidin-3-yl}pyridine-4-carboxamide computational properties antibacterial and MTT assay 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • M. Arshad
    • 1
  • M. Shoeb Khan
    • 2
  • S. A. Asghar Nami
    • 3
  • D. Ahmad
    • 4
  1. 1.Department of Basic Sciences, College of Medicine, Al DawadmiShaqra UniversityShaqraSaudi Arabia
  2. 2.Interdisciplinary Nanotechnology CentreAligarh Muslim UniversityAligarhIndia
  3. 3.Department of Kulliyat, Faculty of Unani MedicineAligarh Muslim UniversityAligarhIndia
  4. 4.College of Pharmacy, Al-DawadmiShaqra UniversityShaqraSaudi Arabia

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