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Russian Journal of General Chemistry

, Volume 88, Issue 10, pp 2144–2148 | Cite as

Synthesis of Amphiphilic Oligomers of Acrylic Acid

  • Ya. O. Mezhuev
  • O. Yu. Sizova
  • A. L. Luss
  • M. I. Shtilman
  • Yu. V. Korshak
Article
  • 8 Downloads

Abstract

Synthesis of amphiphilic oligomers of acrylic acid via radical polymerization in the presence of thiols as molecular mass regulators is described. The effect of the length of the introduced hydrophobic terminal group on the critical micellization concentration of the acrylic acid oligomers has been elucidated. It has been shown that the incorporation of an antituberculous drug (prothionamide) in the micelles of acrylic acid oligomers is enhanced with the increase in the length of the hydrophobic moiety. The preparation of hydroxyapatite-filled calcium-polycarboxylate bone cements containing prothionamide (promising for the sealing of postoperative cavities) is described.

Keywords

amphiphilic polymers polyacrylic acid surfactant prothionamide thiols 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Ya. O. Mezhuev
    • 1
  • O. Yu. Sizova
    • 1
  • A. L. Luss
    • 1
  • M. I. Shtilman
    • 1
  • Yu. V. Korshak
    • 1
  1. 1.Mendeleev University of Chemical Technology of RussiaMoscowRussia

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