Advertisement

Russian Journal of General Chemistry

, Volume 88, Issue 6, pp 1120–1123 | Cite as

Synthesis of 2N-Alkyl-substituted 5-Amino-3-imino-1,2,4-thiadiazolines

  • Yu. V. Butina
  • T. V. Kudayarova
  • E. A. Danilova
Article
  • 16 Downloads

Abstract

Conditions for an efficient and a readily reproducible synthesis of a series of 2N-Alkyl-substituted 5-amino-3-imino-1,2,4-thiadiazolines by the direct alkylation of 3,5-diamino-1,2,4-thiadiazole with alkyl bromides in fairly high yields (up to 76%).

Keywords

3,5-diamino-1,2,4-thiadiazole 2-alkyl-5-amino-3-imino-1,2,4-thiadiazoline alkylation triethylamine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rubtsov, M.V. and Baichikov, A.G., Sinteticheskie khimiko-farmatsevticheskie preparaty (Synthetic Chemical Pharmaceutical Preparations), Moscow: Meditsina, 1971.Google Scholar
  2. 2.
    Mashkovskii, M.D., Lekarstvennye medstva (Drugs), Moscow: Novaya Volna, 2005.Google Scholar
  3. 3.
    Sessler, J.L. and Seidel, D., Angew. Chem. Int. Ed., 2003, vol. 42, p. 5134. doi 10.1002/anie.200200561CrossRefGoogle Scholar
  4. 4.
    Sessler, J.L., Gale, P.A., and Cho, W.S., Anion Receptor Chemistry, Cambridge: Royal Society of Chemistry, 2006.Google Scholar
  5. 5.
    Trukhina, O.N., Rodrnguez-Morgade, M.S., Wolfrum, S., Caballero, E., Snejko, N., Danilova, E.A., Gutiyrrez-Puebla, E., Islyaikin, M.K., Guldi, D.M., and Torres, T., J. Am. Chem. Soc., 2010, vol. 132, p. 12991. doi 10.1021/ja104577dCrossRefPubMedGoogle Scholar
  6. 6.
    RF Patent no. 134270, 1999; Byull. Izobret., 1999, no.22.Google Scholar
  7. 7.
    Novikov, V.E. and Levchenkova, O.S., Nauchn. Vedomosti Belgorod. Gos. Univ., Ser.: Med. Farm., 2012, vol. 20, no. 22, p.130.Google Scholar
  8. 8.
    Levchenkova, O.S., Novikov, V.E., and Botuleva, N.N., Mezhdunarodn. Zh. Prikl. Fundament. Issled., 2014, no. 11, p.452.Google Scholar
  9. 9.
    Kuznetsova, A.S., Danilova, E.A., and Iwyaykin, M.K., Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol., 2014, vol. 57, no. 6, p.43.Google Scholar
  10. 10.
    Holynska, M., Korabik, M., and Kubiak, M., Polyhedron, 2010, vol. 29, no. 1, p. 530. doi 10.1016/j.poly.2009.06.045CrossRefGoogle Scholar
  11. 11.
    Danilova, E.A., Doctoral (Chem.) Dissertation, Ivanovo, 2011.Google Scholar
  12. 12.
    RF Patent no. 2348623, 2009; Byull. Izobret., 2009, no. 7.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Yu. V. Butina
    • 1
  • T. V. Kudayarova
    • 1
  • E. A. Danilova
    • 1
  1. 1.Research Institute of Macroheterocyclic ChemistryIvanovo State University of Chemistry and TechnologyIvanovoRussia

Personalised recommendations