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Russian Journal of General Chemistry

, Volume 88, Issue 6, pp 1095–1102 | Cite as

Synthesis and Biological Activity of Compounds Obtained by Reacting Methyl Aroylpyruvates with Sulfadimidine

  • V. L. Gein
  • O. V. Bobrovskaya
  • M. V. Dmitriev
  • R. R. Makhmudov
  • V. D. Belonogova
Article

Abstract

The reaction of methyl aroylpyruvates and 2-(4-aminobenzenesulfamido)-4,6-dimethylpyrimidine in glacial acetic acid in the presence of anhydrous sodium acetate afforded (2Z)-4-aryl-2-hydroxy-N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-4-oxobut-2-enamides. Reaction of the above reagents in a mixture of acetic acid and ethanol (1: 1) in the absence of anhydrous sodium acetate gave methyl (2Z)-4-aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylamino}-4-oxobut-2-enoates. Analgesic and anti-inflammatory activities of the synthesized compounds was studied.

Keywords

(2Z)-4-aryl-2-hydroxy-N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-4-oxobut-2-enamides 2-(4-aminobenzenesulfamido)-4,6-dimethylpyrimidine (sulfadimidine) methyl (2Z)-4-aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylamino}-4-oxobut-2-enoates analgesic and anti-inflammatory activities 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • V. L. Gein
    • 1
  • O. V. Bobrovskaya
    • 1
  • M. V. Dmitriev
    • 2
  • R. R. Makhmudov
    • 2
  • V. D. Belonogova
    • 1
  1. 1.Perm State Pharmaceutical AcademyPermRussia
  2. 2.Perm State National Research UniversityPermRussia

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