Russian Journal of General Chemistry

, Volume 88, Issue 3, pp 532–536 | Cite as

Synthesis and Antifungal Activity of (±)-4-Methoxy Decanoic Acid and Its Novel Amide Derivatives

  • N. J. P. Subhashini
  • P. Ashok Kumar
  • Ch. Bhaskar Reddy
  • B. Lingaiah
  • Hameeda Bee
Article
  • 9 Downloads

Abstract

A simple synthetic route has been developed for fatty acid, (±)-4-methoxy decanoic acid (1), in 4 steps with 42% overall yield. The novel amide derivatives of 1 are synthesized. The in vitro antifungal activity of 1 and its novel amide derivatives 1a1f has been evaluated against different organisms. Compounds 1e, 1f exhibited antifungal activity higher than the parent compound 1 against macrophomina phaseolina, and 1a, 1d exhibited antifungal activity against sclerotium rolfsii.

Keywords

1,2-epoxyoctane Grignard reaction methylation oxidation 4-methoxy decanoic acid antifungal agent 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • N. J. P. Subhashini
    • 1
  • P. Ashok Kumar
    • 1
  • Ch. Bhaskar Reddy
    • 1
  • B. Lingaiah
    • 1
  • Hameeda Bee
    • 2
  1. 1.Department of Chemistry, University College of ScienceOsmania UniversityHyderabadIndia
  2. 2.Department of Microbiology, University College of ScienceOsmania UniversityHyderabadIndia

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