Russian Journal of General Chemistry

, Volume 87, Issue 11, pp 2648–2653 | Cite as

Synthesis and antimicrobial activity of novel substituted 4-[3-(1H-benzimidazol-2-yl)-4-hydroxybenzyl]-2-(1H-benzimidazol-2-yl)phenol derivatives

  • V. Anil
  • B. Shankar
  • G. Bharath
  • P. JalapathiEmail author


A series of novel substituted bis-benzimidazole derivatives were synthesized by reaction of 5,5′-methylenebis(2-hydroxybenzaldehyde) with various substituted o-phenylenediamines in glacial acetic acid. The structure of the newly synthesized compounds was elucidated by 1H and 13C NMR, FT-IR, and MS spectra, and their antimicrobial activity against gram positive and gram negative bacteria and antifungal activity were evaluated. The thienyl-substituted derivative showed significant activity against Bacillus licheniformis. Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia (bacteria), and Fusarium solani (fungi). The activities of the fluoro-substituted substituted derivative against some bacterial strains and of the thienyl-substituted derivative against fungi were found to be similar to those of standard drugs.


Bis-benzimidazoles acetic acid antibacterial activity antifungal activity 


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© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  1. 1.Department of ChemistryUniversity College of Science, Osmania UniversitySaifabad, Hyderabad, TelanganaIndia
  2. 2.Bioengineering and Environmental Sciences DivisionIndian Institute of Chemical TechnologyHyderabadIndia

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