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Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide

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Abstract

A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.

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Authors and Affiliations

  1. Institute of Organic Synthesis and Coal Chemistry of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, Kazakhstan

    O. A. Nurkenov, Zh. B. Satpaeva & S. D. Fazylov

  2. Montana State University, Bozeman, USA

    I. A. Schepetkin

  3. Russian-Speaking Academic Science Association (RASA) Center, National Research Tomsk Polytechnic University, Tomsk, Russia

    I. A. Schepetkin

  4. National Research Tomsk Polytechnic University, Tomsk, Russia

    A. I. Khlebnikov

  5. Polzunov Altai State Technical University, Barnaul, Russia

    A. I. Khlebnikov

  6. Buketov Karaganda State University, Karaganda, Kazakhstan

    K. M. Turdybekov

  7. Ualikhanov Kokshetau State University, Kokshetau, Kazakhstan

    T. M. Seilkhanov

Authors
  1. O. A. Nurkenov
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  2. Zh. B. Satpaeva
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  3. I. A. Schepetkin
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  4. A. I. Khlebnikov
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  5. K. M. Turdybekov
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  6. T. M. Seilkhanov
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  7. S. D. Fazylov
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Correspondence to O. A. Nurkenov.

Additional information

Original Russian Text © O.A. Nurkenov, Zh.B. Satpaeva, I.A. Schepetkin, A.I. Khlebnikov, K.M. Turdybekov, T.M. Seilkhanov, S.D. Fazylov, 2017, published in Zhurnal Obshchei Khimii, 2017, Vol. 87, No. 10, pp. 1639–1646.

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Nurkenov, O.A., Satpaeva, Z.B., Schepetkin, I.A. et al. Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide. Russ J Gen Chem 87, 2299–2306 (2017). https://doi.org/10.1134/S1070363217100097

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  • DOI: https://doi.org/10.1134/S1070363217100097

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