Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2914–2923 | Cite as

Organo Sn(IV) and Pd(II) complexes with various oxygen and sulphur donor ligands: Synthesis, spectroscopy and biological activity

  • J. Fatima
  • S. Hussain
  • S. AliEmail author
  • S. Shahzadi
  • S. Ramzan
  • M. Shahid


Two Pd(II) complexes, (HL1CSS)2Pd (1) and (KL2CSS)2Pd (2), were synthesized by stirring 2-(1-piperazinyl)ethanol (HL1H)/l-lysine (HL2H) monohydrate in methanol with KOH, CS2 and PdCl2(aq). Homobimetallic (Sn, Sn) products, Ph3SnL3Sn(Cl)Bu2 (3) and Ph3SnL3SnBu3 (4) were produced by refluxing sodium but-2-ynedioate (Na2L3) with Ph3SnCl and Bu2SnCl2 or Ph3SnCl and Bu3SnCl in methanol. A heteronuclear (Sn,Pd) product, [(Bu3Sn)2L2CSS]2Pd (5) was synthesized by the reaction of 5-aminoisophthalic acid (H2L4H), KOH, CS2, PdCl2(aq) with Bu3SnCl. The products were characterized by elemental analysis, FT-IR, UV-Vis, 1H NMR and EIMS. A square planar geometry of Pd(II) and a penta-coordinated environment around Sn(IV) were verified in solid state. The complexes maintain their solid state geometries around Pd(II) even in solutions. Pd(II) complexes 1 and 2 exhibited a significant intercalating mode of binding with salmon sperm DNA. ALPs were inhibited in a concentration dependent manner. Sn(IV) complexes (3 and 4) were inactive against ALPs. Pd(II) complexes (1 and 2) were potent ALPs inhibitors, while the heteronuclear complex 5 was comparatively less active. Organotin(IV) products demonstrated significant antibacterial/ antifungal potential while Pd(II) products were inactive. The heteronuclear (Sn,Pd) product demonstrated moderate inhibition. Among all products, Pd(II) derivative 1 exhibited the highest hemolytic effect.


organic Sn(IV) organic Pd(II) homobimetallic heteronuclear geometry salmon sperm DNA ALPs antibacterial/antifungal hemolytic 


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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • J. Fatima
    • 1
  • S. Hussain
    • 2
  • S. Ali
    • 3
    Email author
  • S. Shahzadi
    • 1
    • 3
  • S. Ramzan
    • 3
  • M. Shahid
    • 4
  1. 1.Department of ChemistryUniversity of Sargodha, Lyallpur CampusFaisalabadPakistan
  2. 2.Department of ChemistryGC UniversityFaisalabadPakistan
  3. 3.Department of ChemistryQuaid-i-Azam UniversityIslamabadPakistan
  4. 4.Department of Chemistry and BiochemistryUniversity of AgricultureFaisalabadPakistan

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