Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2900–2905 | Cite as

Synthesis, characterization, and antimicrobial activity of novel substituted 2H-chromenyl acrylates

  • N. J. P. SubhashiniEmail author
  • M. Ravi
  • D. Cherupally
  • B. China Raju
  • E. V. Reddy
  • H. Bee


The present study deals with conventional Witting olefination of 2H-chromene-3-carbaldehydes with stabilized ylide in the presence of dichloromethane to afford (2E)-ethyl-3-(4-chloro-2H-chromen-3-yl) acrylate derivatives. All the products were found to have E-geometry at C=C bond. The synthesized compounds were characterized by spectral data such as IR, 1H NMR and MS. Compounds were screened for antimicrobial activity against strains of gram positive, gram negative bacterial and fungal strains. All compounds showed good antibacterial and antifungal activity.


substituted phenols 2H-chromene-3-carbaldehydes chromenyl acrylates anti-microbial activity 


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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • N. J. P. Subhashini
    • 1
    Email author
  • M. Ravi
    • 1
  • D. Cherupally
    • 2
  • B. China Raju
    • 2
  • E. V. Reddy
    • 2
  • H. Bee
    • 3
  1. 1.Department of Pharmacy, University College of TechnologyOsmania UniversityHyderabadIndia
  2. 2.Natural Products Chemistry DivisionCSIR Indian Institute of Chemical TechnologyTarnakaIndia
  3. 3.Department of Microbiology, University College of ScienceOsmania UniversityHyderabadIndia

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