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Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2891–2899 | Cite as

Biological evaluation of 4-aryl-1,4-dihydropyridines as VEGFR-2 kinase inhibitors

  • W. Sun
  • Z. Ma
  • H. YanEmail author
Article

Abstract

Vascular endothelial growth factor-2 receptor (VEGFR-2) kinase is a promising target for the development of novel anticancer drugs. Molecular docking modeling was performed on a series of 4-aryl-1,4-dihydropyridines derivatives to evaluate the structural basis for VEGFR-2 inhibitory activity. Some 4-aryl-1,4-dihydropyridines were synthesized in the reaction of aromatic aldehydes and ethyl propiolate with anilines in acetic acid. The biological activities were evaluated against the cells A549, A431 and Hep-G2. The results indicated that 4-aryl-1,4-dihydropyridines could be the promising potential VEGFR-2 inhibitors.

Keywords

VEGFR-2 inhibitors 4-aryl-1,4-dihydropyridines molecular docking biological activity 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.College of Life Science and BioengineeringBeijing University of TechnologyBeijingChina

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