Biological evaluation of 4-aryl-1,4-dihydropyridines as VEGFR-2 kinase inhibitors
- 33 Downloads
Vascular endothelial growth factor-2 receptor (VEGFR-2) kinase is a promising target for the development of novel anticancer drugs. Molecular docking modeling was performed on a series of 4-aryl-1,4-dihydropyridines derivatives to evaluate the structural basis for VEGFR-2 inhibitory activity. Some 4-aryl-1,4-dihydropyridines were synthesized in the reaction of aromatic aldehydes and ethyl propiolate with anilines in acetic acid. The biological activities were evaluated against the cells A549, A431 and Hep-G2. The results indicated that 4-aryl-1,4-dihydropyridines could be the promising potential VEGFR-2 inhibitors.
KeywordsVEGFR-2 inhibitors 4-aryl-1,4-dihydropyridines molecular docking biological activity
Unable to display preview. Download preview PDF.
- 7.Borzilleri, R.M. and Cai, Z.W., WO Patent 2009094417, 2009.Google Scholar
- 10.Yang, Z., Niu, H.Y., Lan, Y.H., and Fu, B.W., Labor. Med. Clin., 2014, vol. 9, p. 024.Google Scholar
- 15.Morris, G.M., Huey, R., and Olson, A.J., Curr. Protocols in Bioinform., 2008, vol. 8, p. 14.Google Scholar
- 16.Chennat, T. and Eisner, U., J. Chem. Soc., 1975, p. 926.Google Scholar