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Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2877–2880 | Cite as

A simplified synthesis of 2-acetyl-1,4,5,8-tetramethoxynaphthalene and its selective demethylation product

  • J. Dong
  • Q. Zhang
  • Q. Meng
  • G. Huang
  • W. ZhouEmail author
  • Shaoshun Li
Article
  • 43 Downloads

Abstract

Based on the Friedel–Crafts acylation reaction, a one-step synthesis of 2-acetyl-1,4,5,8-tetramethoxynaphthalene and its selective demethylation product was carried out under various reaction conditions. The product and yield of the reaction were highly catalyst and solvent dependent. The developed method is characterized by short process time, low cost, mild conditions, simple work-out, high yield, and low chemical waste.

Keywords

Friedel–Crafts acylation selective demethylation Lewis acid synthesis 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • J. Dong
    • 1
  • Q. Zhang
    • 1
  • Q. Meng
    • 1
  • G. Huang
    • 1
  • W. Zhou
    • 1
    Email author
  • Shaoshun Li
    • 1
  1. 1.School of PharmacyShanghai Jiaotong UniversityShanghaiChina

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