A simplified synthesis of 2-acetyl-1,4,5,8-tetramethoxynaphthalene and its selective demethylation product
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Based on the Friedel–Crafts acylation reaction, a one-step synthesis of 2-acetyl-1,4,5,8-tetramethoxynaphthalene and its selective demethylation product was carried out under various reaction conditions. The product and yield of the reaction were highly catalyst and solvent dependent. The developed method is characterized by short process time, low cost, mild conditions, simple work-out, high yield, and low chemical waste.
KeywordsFriedel–Crafts acylation selective demethylation Lewis acid synthesis
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