Synthesis of some new 5-(1-phenyl-1H-1,2,3-triazol-4-yl)-1H-tetrazoles and evaluation of their antimicrobial activity
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a series of new tetrazole derivatives were synthesized by a reaction of triazole oxime with sodium azide catalyzed by copper acetate and isolated with high yield under mild conditions. All synthesized compounds were characterized by IR, NMR, and MS data. Evaluation of antimicrobial activity of the products against Gram-positive and Gram-negative bacterial and antifungal strains has been carried out. Among the compounds 3a, 3c, 3e, and 3f exhibited high antibacterial activity and compounds 3a, 3c, 3e demonstrated high antifungal activity.
Keywordstriazole aldehyde triazlyl tetrazole cupper acetate and antibacterial activity
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- 1.(a)Butler, R.N., in Comprehensive Het. Chem. II, Katritzky, A.R., Rees, C.W., and Scriven, E.F.V., Eds., Oxford: Pergamon Press, 1996, vol. 4, p. 621Google Scholar
- (b).Butler, R.N., in Comprehensive Heterocyclic Chemistry II, Katritzky, A.R., and Rees, C.W., Eds., Oxford: Pergamon Press, 1984, vol. 5, p. 791.Google Scholar
- 3. (a)
- 4. (a)Habu, T., Mii, N., Kuge, K., Manto, H., and Takamuki, Y., J. Imaging Sci., 1991, vol. 35, p. 202Google Scholar
- (b).Hiskey, M., Chavez, D.E., Naud, D.L., Son, S.F., Berghout, H.L., and Bome, C.A., Proc. Int. Pyrotech. Semin., 2000, vol. 27, p. 3.Google Scholar