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Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2862–2864 | Cite as

Synthesis of some new 5-(1-phenyl-1H-1,2,3-triazol-4-yl)-1H-tetrazoles and evaluation of their antimicrobial activity

  • E. NareshEmail author
  • K. Bhaskar
  • G. Linga goud
Article
  • 39 Downloads

Abstract

a series of new tetrazole derivatives were synthesized by a reaction of triazole oxime with sodium azide catalyzed by copper acetate and isolated with high yield under mild conditions. All synthesized compounds were characterized by IR, NMR, and MS data. Evaluation of antimicrobial activity of the products against Gram-positive and Gram-negative bacterial and antifungal strains has been carried out. Among the compounds 3a, 3c, 3e, and 3f exhibited high antibacterial activity and compounds 3a, 3c, 3e demonstrated high antifungal activity.

Keywords

triazole aldehyde triazlyl tetrazole cupper acetate and antibacterial activity 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Green and Medicinal Chemistry Laboratory, Department of ChemistryOsmania UniversityHyderabadIndia

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