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Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2837–2844 | Cite as

Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives

  • A. S. El-AzabEmail author
  • H. A. Ghabbour
  • W. M. El-Husseiny
  • A. R. Maarouf
  • M. A. Mohamed
  • A. A.-M. Abdel-Aziz
Article
  • 105 Downloads

Abstract

Hydrazones 2–22 were synthesized via the reaction of acetophenone with isatin derivatives and anhydrous hydrazine promoted by BF3 as a Lewis acid at 0°C. Structures of the synthesized hydrazones were determined on the basis of NMR and X-ray crystallographic analyses.

Keywords

efficient method N-unsubstituted hydrazone Lewis acids BF3 X-ray crystal structure 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • A. S. El-Azab
    • 1
    • 2
    Email author
  • H. A. Ghabbour
    • 1
    • 3
  • W. M. El-Husseiny
    • 4
  • A. R. Maarouf
    • 3
    • 5
  • M. A. Mohamed
    • 2
    • 6
  • A. A.-M. Abdel-Aziz
    • 1
    • 3
  1. 1.Department of Pharmaceutical Chemistry, College of PharmacyKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Department of Organic Chemistry, Faculty of PharmacyAl-Azhar UniversityCairoEgypt
  3. 3.Department of Medicinal Chemistry, Faculty of PharmacyMansoura UniversityMansouraEgypt
  4. 4.Department of Pharmaceutical Organic Chemistry, Faculty of PharmacyMansoura UniversityMansouraEgypt
  5. 5.Department of Pharmaceutical Chemistry, College of PharmacyDelta University for Science and TechnologyGamasa CityEgypt
  6. 6.Department of Pharmaceutical Chemistry, College of PharmacyPrince Sattam Bin Abdulaziz UniversityAlKharjSaudi Arabia

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