One-pot synthesis of 2-amino-4H-chromenes catalyzed by Fe(ClO4)3/SiO2
- 39 Downloads
A highly efficient one-pot three-component synthesis of 2-amino-3-cyano-4H-chromenes has been developed by annulation of aldehydes, malononitrile and dimedone in the presence of Fe(ClO4)3/SiO2 as a catalyst in acetonitrile under reflux conditions. The simple experimental procedure, short reaction times and high yields are the advantages of this method. A probable mechanism of the process is proposed.
Keywordsthree-component synthesis 2-amino-4H-chromene Fe(ClO4)3/SiO2 catalyst
Unable to display preview. Download preview PDF.