Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2791–2796 | Cite as

Synthesis and antimicrobial evaluation of substituted (1,1'-biphenyl)-4-yl(3-methylbenzofuran-2-yl)methanones by Suzuki cross-coupling reaction

  • B. J. Reddy
  • V. P. ReddyEmail author


A series of new substituted [1,1'-biphenyl]-4-yl(3-methylbenzofuran-2-yl)methanones was prepared by Suzuki cross-coupling from (4-bromophenyl)(3-methylbenzofuran-2-yl)methanone. The obtained compounds were assayed for their in vitro antibacterial activity against different types of bacterial strains; antifungal activity was also examined by inhibitory effect against different fungal strains.


benzofuran Suzuki cross-coupling antimicrobial activity 


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  1. 1.
    Nizami, S.A., Gurumurthy, M., Chattarjee, S., and Panda, D., J. Adv. Pharm. Res., 2010, vol. 1, p. 26.Google Scholar
  2. 2.
    Fittig, R., and Ebert, G., Ann Chem., 1883, vol. 216, p. 162.CrossRefGoogle Scholar
  3. 3.
    Urzua, A., Rezende, M.C., Mascayano, C., and Vásquez, L., Molecules, 2008, vol. 13, p. 882. doi 10.3390/molecules13040822CrossRefGoogle Scholar
  4. 4.
    Aruna Kumar, D.B., Prakash, G.K., Kumarasamy, M.N., Nandheswarappa, B.P., Sheringara, B.S., and Mahadevan, K.M., Indian J. Chem. B, 2007, vol. 46, p. 336.Google Scholar
  5. 5.
    Gundogdu, K.N., Kadriya, B., Yagmur, T., Umit, U., and Seref, D., Eur. J. Med. Chem., 2006, vol. 41, p. 6516. doi 10.1016/j.ejmech.2005.12.013Google Scholar
  6. 6.
    Hayakawa, I., Shioya, R., Agatsuma, T., Furukawa, H., Naruto, S., and Sugano, Y., Bioorg. Med. Chem. Lett., 2004, vol. 14, p. 455. doi 10.1016/j.bmcl.2003.10.039CrossRefGoogle Scholar
  7. 7.
    Galal, S.A., All, A.E., Abdullah M.M., and Diwani, E.H., Bioorg. Med. Chem. Lett., 2009, vol. 19, p. 2420. doi 10.1016/j.bmcl.2009.03.069CrossRefGoogle Scholar
  8. 8.
    Santana, L., Teijeira, M., Uriarte, E., Teran, C., Linares, B., Villar, R., Laguna, R., and Cano, E., Eur. J. Pharm. Sci., 1999, vol. 7, p. 161. doi 10.1016/s0928-0987(98) 00019-0CrossRefGoogle Scholar
  9. 9.
    Kirilmis, C., Ahmedzade, M., Suleyman, S., Koca, M., and Kizirgil, A., Eur. J. Med. Chem., 2008, vol. 43, p. 300. doi 10.1016/j.ejmech.2007.03.023CrossRefGoogle Scholar
  10. 10.
    Aslam, S.N., Stevenson, P.C., Phythian, S.J., Veitch, N.C., and Hall, D.R., Tetrahedron, 2006, vol. 62, p. 4214. doi 10.1016/j.tet.2006.02.015CrossRefGoogle Scholar
  11. 11.
    Malik, W.U., Mahesh, V.K., and Raishighani, M., Indian J. Chem, 1971, vol. 9, p. 655.Google Scholar
  12. 12.
    Fry, D.J., Ficken, E.G., and Burrows. R.W., Brit., 1969, vol. 1, p. 168495.Google Scholar
  13. 13.
    Brady, B.A., Kennedy, J.A., and Sullivan, W.I., Tetrahedron, 1973, vol. 29, p. 359. doi 10.1016/s0040- 4020(01)93302-2CrossRefGoogle Scholar
  14. 14.
    Modern Arylation Methods, Ackermann, L., Ed., Wiley- VCH, Weinheim, 2009.Google Scholar
  15. 15.
    Suzuki, A., Boronic Acids. Preparation, Applications in Organic Synthesis and Medicine, Weinheim: Wiely-VHC, 2005, p. 123.Google Scholar
  16. 16.
    Bringmann, G., Mortimer, A.J.P., Keller, P.A., Gresser, M.J., Garner, J., and Breuning, M., Angew. Chem. Int. Ed., 2005, vol. 44, p. 5384. doi 10.1002/anie20046261CrossRefGoogle Scholar
  17. 17.
    Miyaura, N., Yamada, K., and Suzuki, A., Tetrahedron Lett., 1979, vol. 20, p. 3437.CrossRefGoogle Scholar
  18. 18.
    Suzuki, A., Pure Appl. Chem., 1994, vol. 66, p. 213. doi 10.1351/pac199466020213CrossRefGoogle Scholar
  19. 19.
    Suzuki, A., Pure Appl. Chem., 1991, vol. 63, p. 419. doi 10.1351/pac199163030419CrossRefGoogle Scholar
  20. 20.
    Miyaura, N., and Suzuki, A., Chem. Rev., 1995, vol. 95, p. 2457.CrossRefGoogle Scholar
  21. 21.
    Alonso, F., Beletskaya, I.P., and Yus, M., Tetrahedron, 2008, vol. 64, p. 3047. doi 10.1016/j.tet.2007.12.036CrossRefGoogle Scholar
  22. 22.
    Mondal, M., and Bora, U., Green Chem., 2012, vol. 14, p. 1873. doi 10.1039/c2gc354016CrossRefGoogle Scholar
  23. 23.
    Yadav, N., Hussain, M.K., Ansari, M.I., Gupta P.K., and Hajela, K., RSC Advances, 2013, vol. 3, p. 540. doi 10.1039/C2RA22355DCrossRefGoogle Scholar
  24. 24.
    Ajjanna, M.S., Venugopala Reddy, K.R., Keshavayya, J., Ambika, V., Gopinath, V.S., Bosei, P., Goud, S.K., and PeethambarI, S.K., J. Braz. Chem. Soc., 2011, vol. 22, p. 849. doi 10.1590/s0103-50532011000500006CrossRefGoogle Scholar
  25. 25.
    Song, S.Q., Zhou, L.G., Li, D., Tang, D., Li, J.Q., and Jiang, W.B., Nat. Prod. Res. Dev., 2004, vol. 16, p. 157.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Department of ChemistryOsmania UniversityHyderabadIndia

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