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Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2785–2790 | Cite as

Synthesis, characterization, and antimicrobial activity of some chiral linear carboxamides with incorporated peptide linkage

  • N. M. Khalifa
  • A. E. G. Amr
  • M. A. Al-Omar
  • E. S. Nossier
Article

Abstract

A new group of chiral linear 7-methyl-4-oxo-1,8-naphthyridine-3-carboxamides with incorporated peptide linkage have been synthesized via condensation of 1-ethyl-N-(1-hydrazinyl-3-methyl-1-oxobutan-2-yl)-7-methyl–4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide with various derivatives of sugar pentose, acetophenones and thiosemicarbazide. Structures of the products were elucidated by spectroscopic methods and chemical analysis. Antimicrobial properties of the synthesized compounds were tested.

Keywords

carboxamide derivatives peptides antimicrobial activity 

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References

  1. 1.
    Splith, K. and Neundorf, I., Eur. Biophys. J., 2011, vol. 40, p. 387. doi 10.1007/s00249-011-0682-7CrossRefGoogle Scholar
  2. 2.
    Yeaman, R. and Yount, Y., Pharmacol. Rev., 2003, vol. 55, p. 27. doi 10.1124/pr.55.1.2CrossRefGoogle Scholar
  3. 3.
    Hoskin, W. and Ramamoorthy, A., Biochim. Biophys. Acta, 2008, vol. 1778(2), p. 357. doi 10.1016/j.bbamem.2007.11.008CrossRefGoogle Scholar
  4. 4.
    Vivek, I., Manu, J., Anu, S., Alka, M., Vinod, S., Pratibha, S., Pramod, K. Sharma, c, Raghuveer, I., and Anand, B., Eur. J. Med. Chem., 2009, vol. 44, p. 3356. doi 10.1016/j.ejmech.2009.03.015CrossRefGoogle Scholar
  5. 5.
    Henderson, J.M., Waring, A.J., Separovic, F., and Lee, K.Y., Biophys J.., 2016, vol. 111(10), p. 2176. doi 10.1016/j.bpj.2016.10.003Google Scholar
  6. 6.
    Shao, Y., Wang, Z., Tian, X., Guo, Y., and Zhang, H., Int. J. Biol. Macromol. 2016, vol. 85, p. 573. doi 10.1016/j.ijbiomac.2016.01.031Google Scholar
  7. 7.
    Embrey, W, Wai, S., Funk, W., Homnick, F., Perlow, S., Young, D., Vacca, P., Hazuda, J., Felock, J., Stillmock, A., Witmer, V., Moyer, G., Schleif, A., Gabryelski, J., Jin, L., Chen, I-Wu., Ellis, D., Wong, K., Lin, H., Leonard, M., Tsou N., and Zhuang, L. Bioorg. Med. Chem. Lett., 2005, vol. 15, p. 4550. doi 10.1016/j.bmcl.2005.06.105CrossRefGoogle Scholar
  8. 8.
    Atanasova, M., Ilieva, S., and Galabov, B., Euro. J. Med. Chem., 2007, vol. 42, p. 1184. doi 10.1016/j.ejmech.2007.01.029CrossRefGoogle Scholar
  9. 9.
    Hu, W., Yu, H., Chen, Y., Tsai, Y., Liao, K., Chang, C., and Wang, L., Bioorg. Med. Chem., 2008, vol. 16, p. 5295. doi 10.1016/j.bmc.2008.03.003CrossRefGoogle Scholar
  10. 10.
    Di Braccio, M., Grossi, G., Alfei, S., Ballabeni, V., Tognolini, M., Flammini, L., Giorgio, C., Bertoni, S., and Barocelli, E., Eur. J. Med. Chem., 2014, vol. 86, p. 394. doi 10.1016/j.ejmech.2014.08.069CrossRefGoogle Scholar
  11. 11.
    de Beer, E. and Sherwood, M., J. Bacteriol., 1945, vol. 50, p. 459. PMID 21008209.PubMedPubMedCentralGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • N. M. Khalifa
    • 1
    • 2
  • A. E. G. Amr
    • 1
    • 3
  • M. A. Al-Omar
    • 1
  • E. S. Nossier
    • 4
  1. 1.Pharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of PharmacyKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Theripeutical Chemistry DepartmentNational Research CentreDokki, CairoEgypt
  3. 3.Applied Organic Chemistry DepartmentNational Research CentreDokki, CairoEgypt
  4. 4.Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls)Al-Azhar UniversityCairoEgypt

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