Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2785–2790 | Cite as

Synthesis, characterization, and antimicrobial activity of some chiral linear carboxamides with incorporated peptide linkage

  • N. M. Khalifa
  • A. E. G. Amr
  • M. A. Al-Omar
  • E. S. Nossier


A new group of chiral linear 7-methyl-4-oxo-1,8-naphthyridine-3-carboxamides with incorporated peptide linkage have been synthesized via condensation of 1-ethyl-N-(1-hydrazinyl-3-methyl-1-oxobutan-2-yl)-7-methyl–4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide with various derivatives of sugar pentose, acetophenones and thiosemicarbazide. Structures of the products were elucidated by spectroscopic methods and chemical analysis. Antimicrobial properties of the synthesized compounds were tested.


carboxamide derivatives peptides antimicrobial activity 


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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • N. M. Khalifa
    • 1
    • 2
  • A. E. G. Amr
    • 1
    • 3
  • M. A. Al-Omar
    • 1
  • E. S. Nossier
    • 4
  1. 1.Pharmaceutical Chemistry Department, Drug Exploration & Development Chair, College of PharmacyKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Theripeutical Chemistry DepartmentNational Research CentreDokki, CairoEgypt
  3. 3.Applied Organic Chemistry DepartmentNational Research CentreDokki, CairoEgypt
  4. 4.Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls)Al-Azhar UniversityCairoEgypt

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