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Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2777–2784 | Cite as

Microwave-assisted synthesis of pyrazole-based 1,2,3-triazole derivatives and evaluation of their antimicrobial activity

  • N. J. P. Subhashini
  • K. Sravanthi
  • Ch. Sravanthi
  • M. S. Reddy
Article

Abstract

A series of new pyrazole-based 1,2,3-triazole derivatives were synthesized through the microwave-assisted Huisgen click reaction from 1-phenyl-3-[3-(prop-2-yn-1-yloxy)phenyl]-1H-pyrazole-4-carbaldehyde and organic azides with the use of redox system CuSO4·5H2O–sodium ascorbate. The method provided short reaction times and isolation of 1,4-disubstituted 1,2,3-triazoles in high yield. All the prepared compounds were evaluated for antimicrobial activity and the most of them displayed promising results.

Keywords

Huisgen click reaction pyrazole-4-carboxaldehydes 1,2,3-triazoles microwave-assisted reactions antimicrobial activity 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • N. J. P. Subhashini
    • 1
  • K. Sravanthi
    • 1
  • Ch. Sravanthi
    • 1
  • M. S. Reddy
    • 2
  1. 1.Department of Chemistry, University College of TechnologyOsmania UniversityHyderabadIndia
  2. 2.Department of Pharmaceutical ChemistryVaageswari College of PharmacyThimmapur, KarimnagarIndia

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