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Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2752–2758 | Cite as

Synthesis and characterization of novel 5-allyl-6-{(benzo[d]thiazol-2-yl)methyl}-2-(alkylsulfanyl)oxopyrimidine derivatives

  • N. M. KhalifaEmail author
  • M. A. Al-Omar
  • A. E. Amr
Article
  • 25 Downloads

Abstract

A series of novel S-DABO analogues bearing thiazolo[3,2-a]pyrimidine and pyrimido[2,1-b][1,3]thiazine has been developed starting from 5-allyl-6-{(benzo[d]thiazol-2-yl)methyl}-2,3-dihydro-2-thioxopyrimidin-4(1H)-one. Selective S-alkylation was achieved to give the title compounds which were cyclized and oxidized to the corresponding sulfones.

Keywords

S-DABO analogues benzo[d]thiazoles pyrimidine-4-one derivatives synthesis 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of PharmacyKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries DivisionNational Research CentreDokki, CairoEgypt
  3. 3.Applied Organic Chemistry DepartmentNational Research CentreDokki, CairoEgypt

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