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Russian Journal of General Chemistry

, Volume 86, Issue 12, pp 2666–2670 | Cite as

Synthesis and antimicrobial activity of N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides

  • V. L. GeinEmail author
  • T. M. Zamaraeva
  • A. V. Balandina
  • M. V. Dmitriev
Article

Abstract

Three-component reactions of acetoacetic acid N-arylamides, aromatic aldehydes, and thiourea afforded N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Structure and antimicrobial activity of the compounds obtained were examined.

Keywords

three-component reaction N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides antimicrobial activity 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • V. L. Gein
    • 1
    Email author
  • T. M. Zamaraeva
    • 1
  • A. V. Balandina
    • 1
  • M. V. Dmitriev
    • 2
  1. 1.Perm State Pharmaceutical AcademyMinistry of Healthcare of the Russian FederationPermRussia
  2. 2.Perm State National Research UniversityPermRussia

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