Russian Journal of General Chemistry

, Volume 86, Issue 5, pp 1137–1143 | Cite as

Synthesis, characterization, and cytotoxic in vitro studies of the antibiotic drug metronidazole complexed with Au(III), Fe(III), Pd(III), and Zn(II): Toward potent gold-drug nanoparticles in cancer chemotherapy

  • A. M. A. AdamEmail author


Prolifiration of cancer incidents over recent decades has motivated researchers to explore new metal complexes with potential anticancer properties as alternative chemotherapeutic agents in clinical treatments. Au3+, Fe3+, Pd3+, and Zn2+ complexes of the drug metronidazole (MZ) were synthesized and characterized in the current study by elemental analysis, magnetic moment, molar conductance, UV–Vis, IR, Raman, and 1H NMR spectroscopy. Morphology and nanometry of the complexes have been studied by XRD, SEM, and TEM techniques. In vitro cytotoxicity of the Au(III) complex against two human tumor cell lines was assessed by the MTT method. The Au(III) complex formed well-organized nanoparticles with the main diameter in the range of 6–34 nm. It exhibited the significant cytotoxic effect against human hepatocellular carcinoma cells with potency caю 7.5 times greater than that of free MZ.


metronidazole Au(III) complex cytotoxic activity nanoparticles 


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  1. 1.
    Mjos, K.D. and Orvig, C., Chem. Rev., 2014, vol. 114, p. 4540. DOI: 10.1021/cr400460s.CrossRefGoogle Scholar
  2. 2.
    Pagoto, T.M.P., Sobrinho, L.L.G., Graminha, A.E., Guedes, A.P.M., Carroccia, M.C., de Oliveira, P.F., Silveira-Lacerda, E.P., Deflon, V.M., Tavares, D.C., Pivatto, M. Batista, Von Poelhsitz, G., C.R. Chimie, 2015. DOI: 10.1016/jcrci.2015.07.008.Google Scholar
  3. 3.
    Guidi, F., Modesti, A., Landini, I., Nobili, S., Mini, E., Bini, L., Puglia, M., Casini, A., Dyson, P.J., Gabbiani, C., and Messori, L., J. Inorg. Biochem., 2013, vol. 118, p. 94. DOI: 10.1016/jjinorgbio.2012.10.003.CrossRefGoogle Scholar
  4. 4.
    Lai, S., Jiang, G., Yao, J., Li, W., Han, B., Zhang, C., Zeng, C., and Liu, Y., J. Inorg. Biochem., 2015, vol. 152, p. 1. DOI: 10.1016/jjinorgbio.2015.08.012.CrossRefGoogle Scholar
  5. 5.
    Breccia, A., Cavalleri, B., and Adam, G.E., Nitroimidazoles: Chemistry, Pharmacology, and Clinical Application, New York Plenum Press, 1982.CrossRefGoogle Scholar
  6. 6.
    Adams, G.E., Clarke, C., Dawson, K.B., Sheldon, P.W., and Stratford, I.J., in Biological Bases and Clinical Implications of Tumor Radioresistance, Fletcher, G.H., Nervi, C., and Whiters, H.R., Eds., New York Masson, 1983.Google Scholar
  7. 7.
    Huang, X.J., Lin, J.B., and Yuan, D.X., J. Sep. Sci., 2011, vol. 34, p. 2138. DOI: 10.1002/jssc.201000880.Google Scholar
  8. 8.
    Beena, N., Kumar, R.K., Rohilla, N., and Roy, D.S., Bioorg. Med. Chem. Lett., 2009, vol. 19, p. 1396. DOI: 10.1016/jbmcl.2009.01.037CrossRefGoogle Scholar
  9. 9.
    Miljkovic, V., Arsic, B., Bojanic, Z., Nikolic, G., Nikolic, L.J., Kalicanin, B., and Savic, V., Pharmazie, 2014, vol. 69, p. 571. DOI: 10.1691/ph.2014.3951.Google Scholar
  10. 10.
    Soares, G.M.S., Figueiredo, L.C., Faveri, M., Cortelli, S.C., Duarte, P.M., and Feres, M., J. Appl. Oral Sci., 2012, vol. 20, p. 295. DOI: 10.1590/S1678-77572012000300002.CrossRefGoogle Scholar
  11. 11.
    Chen, D., Deng, J., Liang, J., Xie, J., Hu, C., and Huang, K., Sensors Actuators B, 2014, vol. 183, p. 594. DOI: 10.1016/jsnb.2013.04.050.CrossRefGoogle Scholar
  12. 12.
    Chen, T., Chen, L., Li, H., Chen, Y., Guo, H., Shu, Y., Chen, Z., Cai, C., Guo, L., Zhang, X., Zhou, L., and Zhong, Q., Colloid. Surf. B, 2014, vol. 118, p. 65. DOI: 10.1016/jcolsurfb.2014.02.011.CrossRefGoogle Scholar
  13. 13.
    Fu, L., Liu, X.-F., Zhou, Q.-X., Zhang, J.-X., Dong, J.-Y., and Wang, J.-F., J. Luminescence, 2014, vol. 149, p. 208. DOI: 10.1016/jjlumin.2014.01.023.CrossRefGoogle Scholar
  14. 14.
    Zhang, L., Kumar, K.V., Geng, R., and Zhou, C., Bioorg. Med. Chem. Lett., 2015, vol. 25, p. 3699. DOI: 10.1016/jbmcl.2015.06.041.CrossRefGoogle Scholar
  15. 15.
    Callaghan, V., Goodgame, D.M.L., and Tooze, R.P., Inorg. Chim. Acta, 1983, vol. 78, p. L1. DOI: 10.1016/S0020-1693(00)86458-0.CrossRefGoogle Scholar
  16. 16.
    Dyson, T.M., Morrison, E.C., and Tocher, D.A., Inorg. Chim. Acta, 1990, vol. 169, p. 127. DOI: 10.1016/S0020-1693(00)82045-9.CrossRefGoogle Scholar
  17. 17.
    Barba-Behrens, N., Mutio-Rico, A.M., Joseph-Nathan, P., and Contreras, R., Polyhedron, 1991, vol. 10, p. 1333. DOI: 10.1016/S0277-5387(00)81266-8.CrossRefGoogle Scholar
  18. 18.
    Galván-Tejada, N., Bernès, S., Castillo-Blum, S.E., Nöth, H., Vicente, R., and Barba-Behrens, N., J. Inorg. Biochem., 2002, vol. 91, p. 339. DOI: 10.1016/S0162-0134(02)00468-3.CrossRefGoogle Scholar
  19. 19.
    Obaleye, J.A. and Lawal, A., J. Appl. Sci. Environ. Manage, 2007, vol. 11, no. 4, p. 15. http://hdlhandlenet/1807/51567.Google Scholar
  20. 20.
    Palmer, J.H., Wu, J., and Upmacis, R.K., J. Mol. Struct., 2015, vol. 1091, p. 177. DOI: 10.1016/jmolstruc.2015.02.057.CrossRefGoogle Scholar
  21. 21.
    Cotton, F.A., Goodgame, D.M.L., and Goodgame, M., J. Am. Chem. Soc., 1962, vol. 84, p. 167. DOI: 10.1021/ja00861a008.CrossRefGoogle Scholar
  22. 22.
    Abdalrazaq, E.A., Buttrus, N.H., and Abd Al-Rahman, A.A., Assian J. Chem., 2010, vol. 22, no. 3, p. 2179.Google Scholar
  23. 23.
    Al-Khodir, F.A.I. and Refat, M.S., J. Mol. Struct., 2015, vol. 1094, p. 22. DOI: 10.1016/jmolstruc.2015.03.063.CrossRefGoogle Scholar
  24. 24.
    Refat, M.S., Saad, H.A., and Adam, A.M.A., Spectrochim. Acta A, 2015, vol. 141, p. 202. DOI: 10.1016/jsaa.2015.01.029.CrossRefGoogle Scholar
  25. 25.
    Al-Khodir, F.A.I. and Refat, M.S., J. Pharm. Innov., 2015, vol. 10, no. 4, p. 335. DOI: 10.1007/s12247-015-9230-9.CrossRefGoogle Scholar
  26. 26.
    Chamundeeswari, S.P.V., Samuel, E.R.J.J., and Sundaraganesan, N., Eur. J. Chem., 2011, vol. 2, no. 2, p. 136.CrossRefGoogle Scholar
  27. 27.
    Mossman, T., J. Immunol. Methods, 1983, vol. 65, p. 55. DOI: 10.1016/0022-1759(83)90303-4.CrossRefGoogle Scholar

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© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceTaif University, Al-HaweiahTaifSaudi Arabia

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