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Russian Journal of General Chemistry

, Volume 85, Issue 2, pp 467–471 | Cite as

Synthesis, steric structure, and biological activity of 5-methyl-2-(morpholin-4-ylamino)-5,6-dihydro-4H-1,3-thiazin-4-one

  • I. V. KulakovEmail author
  • Z. T. Shulgau
  • K. M. Turdybekov
  • D. M. Turdybekov
  • D. T. Sadyrbekov
Article

Abstract

New 5,6-dihydro-1,3-thiazin-4-one derivatives have been synthesized by one-pot reaction of morpholin-4-amine and adamantan-1-amine with methacryloyl isothiocyanate. Structure of 5-methyl-2-(morpholin-4-ylamino)-5,6-dihydro-4H-1,3-thiazin-4-one has been determined by X-ray analysis, and its high antiradical and anti-inflammatory activity has been revealed.

Keywords

morpholin-4-amine adamantan-1-amine methacryloyl isothiocyanate 5,6-dihydro-1,3-thiazin-4-one intramolecular cyclization antiradical activity anti-inflammatory activity 

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • I. V. Kulakov
    • 1
    Email author
  • Z. T. Shulgau
    • 2
  • K. M. Turdybekov
    • 3
  • D. M. Turdybekov
    • 3
  • D. T. Sadyrbekov
    • 2
  1. 1.Dostoevskii Omsk State UniversityOmskRussia
  2. 2.Life Science CenterNazarbayev UniversityAstanaRepublic of Kazakhstan
  3. 3.Karaganda State Technical UniversityKaragandaRepublic of Kazakhstan

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