Russian Journal of General Chemistry

, Volume 81, Issue 1, pp 96–101 | Cite as

Synthesis and biological activity of the pinostrobin oxime complex compounds with some d-metals

  • A. A. Mashentseva
  • T. S. Seytembetov
  • S. M. Adekenov
  • B. I. Tuleuov
  • O. P. Loiko
  • A. I. Khalitova
Article

Abstract

The process of the complex formation by the natural flavonoid pinostrobin (5-hydroxy-7-methoxyflavonone) oxime with the Cu(II) and Fe(III) ions in a water-ethanol medium was investigated. The metal: ligand ratio in the complex was determined by the saturation method. The results of the analysis of IR spectra and the data of mass-spectrometric studies of the structure of the obtained complex compounds are reported. The antiviral activity of the synthesized complexes with respect to the human immunodeficiency virus HIV-1 IIIB and HIV-2 ROD strains was studied. The antioxidant activity of the complexes, as well as the parent pinostrobin oxime ligand, was evaluated with respect to the diphenylpicrylhydrazyl (DPPH) radical and the 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical cation.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kostyuk, V.A. and Potapovich, A.I., Bioradikaly i bioantioksidanty (Bioradicals and Bioantioxidants), Moscow: BGU, 2004.Google Scholar
  2. 2.
    Moridani Majid, Y., Pourahmad, J., and Hoang, B., Free Radical Biology and Medicine, 2003, vol. 34, no. 2, p. 243.CrossRefGoogle Scholar
  3. 3.
    Perez, C.A., Yong Tong, and Maolin Guo, Curr. Bioact. Compd., 2008, vol. 4(3), p. 150.CrossRefGoogle Scholar
  4. 4.
    Bravo, A. and Anacona, J., Transition Met. Chem., 2001, vol. 26, p. 20CrossRefGoogle Scholar
  5. 5.
    Weijun Chen, Shaofang Sun, Wei Cao, Yan Liang, and Jirong Song, J. Mol. Struct., 2009, vol. 918, p. 194.CrossRefGoogle Scholar
  6. 6.
    Horsfall, J.G., Principles of Fungicidal Action, Waltham: Chronica Botanica Co., 1956, p. 141.Google Scholar
  7. 7.
    Bukharia, S.B., Shahabuddin, M., Mahroof-Tahirc, M., and Bhanger, M.I., Spectrochim. Acta, A, 2009, vol. 71, p. 1901.CrossRefGoogle Scholar
  8. 8.
    Arman, P. and Wain, R.L., Ann. Appl. Biol., 1958, vol. 46, p. 366.CrossRefGoogle Scholar
  9. 9.
    Kostyuk, V.A., Potapovich, A.I., and Strigunova, E.N., Arch. Biochem. Biophys., 2004, vol. 428, p. 204.CrossRefGoogle Scholar
  10. 10.
    Bukharia, S.B., Shahabuddin, M., Mahroof-Tahirc, M., and Bhanger, M.I., J. Mol. Struct., 2008, vol. 892, p. 39.CrossRefGoogle Scholar
  11. 11.
    Stavrescu, R.B., Kimura, T., Hayakawa, F., and Ando, T., Central Eur. J. Chem., 2003, no. 1, p. 35.Google Scholar
  12. 12.
    Korostelev, P.P., Prigotovlenie rastvorov dlya khimikoanaliticheskikh rabot (Preparation of Solutions for the Chemical Analytical Work), Moscow: Akad. Nauk SSSR, 1962.Google Scholar
  13. 13.
    Osnovy analiticheskoi khimii (Fundamentals of Analytical Chemistry), Zolotov, Yu.A., Ed., Moscow: Vysshaya Shkola, 2001.Google Scholar
  14. 14.
    Brand-Williams, W., Cuvelier, M.E., and Berset, C., Lebensmittel Wissenschaft und Technologie, 1995, vol. 28, p. 25.Google Scholar
  15. 15.
    Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., and Rice-Evans, C., Free Radical Biology and Medicine, 1999, vol. 26(9), p. 1231.CrossRefGoogle Scholar
  16. 16.
    Bulatov, M.I. and Kalinkin, I.P., Prakticheskoe rukovodstvo po fotometricheskim metodam analiza (Practical Manual on the Photometric Methods of Analysis), Leningrad: Nauka, 1976.Google Scholar
  17. 17.
    Lagunin, A., Stepanchikova, A., Filimonov, D., and Poroikov, V., Bioinformatics, 2000, vol. 16, no. 8, p. 747.CrossRefGoogle Scholar
  18. 18.
    Kopacz, M., Woznicka, E., and Gruszecka, J., Acta Polon. Pharm. Drug Research, 2005, vol. 62, no. 1, p. 65.Google Scholar
  19. 19.
    Cornard, J.P. and Merlin, J.C., J. Inorg. Biochem., 2002, vol. 92, p. 19.CrossRefGoogle Scholar
  20. 20.
    Pannecouque, C., Daelemans, D., and De Clercq, E., Nature Protocols, 2008, no. 3, p. 427.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • A. A. Mashentseva
    • 1
  • T. S. Seytembetov
    • 1
  • S. M. Adekenov
    • 2
  • B. I. Tuleuov
    • 2
  • O. P. Loiko
    • 3
  • A. I. Khalitova
    • 3
  1. 1.Gumilev Eurasian National UniversityAstanaKazakhstan
  2. 2.International Holding “Phytochemistry,”KaragandaKazakhstan
  3. 3.Buketov Karaganda State UniversityKaragandaKazakhstan

Personalised recommendations