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Russian Journal of Coordination Chemistry

, Volume 45, Issue 11, pp 817–823 | Cite as

A New Coordination Polymer for Effective 5-fluorouracil Loading and Anti-lung Cancer Activity Study

  • L. Y. Shi
  • W. Zhang
  • G. Z. Zhou
  • Q. CaoEmail author
Article
  • 2 Downloads

Abstract

A new three-dimensional porous coordination polymer with the formula of [Ba(HTATB)-(H2O)](DMF)2 (I) has been solvothermally synthesized from 4,4′,4″-s-triazine-2,4,6-triyltribenzoic acid (H3TATB) and Ba(NO3)2 under DMF media and characterized by single crystal X-ray diffraction (CIF file CCDC no. 1856562) and elemental analysis. The efficient encapsulation of an anticancer drug 5-fluorouracil (5-FU) on the desolvated I (Ia) has been studied both experimentally and computationally. In addition, in vitro anti-lung cancer activity of compounds I and 5-FU loaded 1a have also been evaluated using MTT assay.

Keywords:

three-dimensional encapsulation X-ray anti-liver cancer activity 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Department of Respiratory and Critical Care Medicine, Affiliated Baoji Hospital of Xi’an Medical UniversityBaojiP.R. China
  2. 2.The Affiliated Hospital of Yan’An UniversityYan’AnP.R. China
  3. 3.Respiratory Department of Ankang Traditional Chinese Medicine HospitalAnkangP.R. China

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