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Russian Journal of Coordination Chemistry

, Volume 44, Issue 11, pp 701–706 | Cite as

Synthesis, Crystal Structures and Insulin-Enhancing Activity of Vanadium(V) Complexes with Hydrazone Ligands

  • S. Y. Li
  • W. Q. Zhai
  • Z. W. Li
  • A. Li
  • Y. M. Jiang
  • W. Li
Article

Abstract

Two new isostructurally mononuclear vanadium(V) complexes, [VO(L1)(OMe)(MeOH)] (I) and [VO(L2)(OMe)(MeOH)] (II), where L1 and L2 are the dianionic form of 2-chloro-N'-(3,5-dibromo-2-hydroxybenzylidene)benzohydrazide and 2-bromo-N'-(3,5-dibromo-2-hydroxybenzylidene)benzohydrazide, respectively, have been prepared. The complexes have been characterized by physico-chemical methods and single crystal X-ray determination (CIF files CCDC nos. 1824513 (I) and 1824514 (II)). The V atoms in both complexes are coordinated by the three donor atoms of the hydrazone ligands, two O atoms from one deprotonated methanol ligand and one neutral methanol ligand, and one oxo group, forming octahedral coordination. Insulin-mimetic tests on C2C12 muscle cells using biovision glucose assay indicates that the complexes significantly stimulated cell glucose utilization with cytotoxicity at 0.15 g L–1.

Кeуwords: hydrazone, vanadium complex crystal structure X-ray diffraction insulin mimetic 

Notes

ACKNOWLEDGMENTS

This work was financially supported by the Scientific Research Training Program of Liaoning Normal University (project no. cx201802017).

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • S. Y. Li
    • 1
  • W. Q. Zhai
    • 2
  • Z. W. Li
    • 2
  • A. Li
    • 2
  • Y. M. Jiang
    • 2
  • W. Li
    • 1
    • 3
  1. 1.Department of Radiology, the Second Hospital of Dalian Medical UniversityDalianP.R. China
  2. 2.Department of Chemistry and Chemical Engineering, Liaoning Normal UniversityDalianP.R. China
  3. 3.Department of Hepatobiliary and Pancreatic Surgery, the Second Hospital of Dalian Medical UniversityDalianP.R. China

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