Platinum Polyoxoniobates Form Adducts with DNA

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Platinum complexes are among the most commonly prescribed drugs in cancer therapy but show significant toxicity to healthy tissues as a side effect. Platinum polyoxometalates are platinum complexes liganded with cluster anions consisting of oxygen atoms and transition metals. Their properties related to a potential use as anticancer drugs have never been studied. In this paper, we have investigated the effect of platinum (IV) polyoxoniobate of the [Nb6O19{Pt(OH)2}]2 structure containing two platinum centers and two polynuclear Lindqvist type anions on the activity of a number of DNA polymerases belonging to different families (Klenow fragment of Escherichia coli DNA polymerase I, bacteriophage RB69 DNA polymerase, human DNA polymerases β and κ, DNA polymerase IV from Sulfolobus solfataricus). On its own, platinum polyoxoniobate did not act as an inhibitor of DNA polymerases, but was capable of forming adducts with DNA.

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Correspondence to D. O. Zharkov.

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This article does not contain any studies involving animals or human participants performed by any of the authors.

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Authors declare that they have no conflicts of interests.

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Translated by M. Novikova

Abbreviations: DTT, dithiothreitol; EDTA, ethylenediaminetetraacetic acid; KF, Klenow fragment of Escherichia coli DNA polymerase I; ODN, oligodeoxyribonucleotide; Pt-PON, platinum polyoxoniobate.

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Yudkina, A., Sokolov, M., Abramov, P. et al. Platinum Polyoxoniobates Form Adducts with DNA. Russ J Bioorg Chem 45, 641–646 (2019).

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  • polyoxometalates
  • DNA polymerases
  • DNA damage