Russian Journal of Bioorganic Chemistry

, Volume 45, Issue 6, pp 575–584 | Cite as

Synthesis and Biological Evaluation of Some Succinimide Hybrid Molecules

  • Fatih Yılmaz
  • Emre MenteşeEmail author
  • Nimet Baltaş


In this study, a new series of succinimide hybrid molecules containing isothiocyanate, coumarin, isatin, and furan moieties was synthesized and screened for α-glucosidase and antioxidant activities. Preliminary results revealed that all molecules showed good α-glucosidase inhibition effectiveness. Antioxidant activities of the hybrid molecules were determined using cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) assays. Also, the radical scavenging activities of the synthesized compounds were assayed by using \({\text{ABT}}{{{\text{S}}}^{{\centerdot {\text{ + }}}}}\) and \({\text{DPP}}{{{\text{H}}}^{\centerdot }}\) methods. The results showed that all compounds exhibited moderated to high scavenging activity.


pyrrolidine-2,5-diones α-glucosidase coumarin isatin furan antioxidant activity 



The work has no studies involving humans or animals as subjects of the study.

Conflict of Interests

Authors declare that they have no conflicts of interests.


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Vocational School of Technical Studies, Department of Chemistry and Chemical Processing Technology, Recep Tayyip Erdogan UniversityRizeTurkey
  2. 2.Department of Chemistry, Faculty of Arts and Sciences, Recep Tayyip Erdogan UniversityRizeTurkey

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