Synthesis and Biological Evaluation of Novel Steroidal 5α,8α-Endoperoxide Derivatives with Aromatic Hydrazone Side Chain as Potential Anticancer Agents
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Seven new steroidal 5α,8α-endoperoxide derivatives with C-17 aromatic hydrazone side chain were synthesized. Structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectrometry. Anti-proliferative activities of the synthesized compounds were evaluated in vitro by the MTT method. Among the seven compounds, 5α,8α-epidioxy-17-(4-chloro-benzylidene)-hydrazonoandrost-3β-ol showed the strongest anti-proliferative activity against three human cancer cell lines (MCF-7, HepG2, and SK-Hep1).
Keywords:steroid ergosterol peroxide dehydroepiandrosterone dihydrazone antitumor activity
This study was supported by Qiqihar Academy of Medical Sciences Project (QMSI 2017B-09).
COMPLIANCE WITH ETHICAL STANDARDS
The work has no studies involving humans or animals as subjects of the study.
Conflict of Interests
Authors declare that they have no conflicts of interests.
- 11.Li, X.M., Wu, Q.P., Bu, M., Hu, L.M., Du, W.W., Jiao, C.W., Pan, H.H., Sdiri, M., Wu, N., Xie, Y.Z., and Yang, B.B., Oncotarget, 2016, vol. 7, pp. 33 948–33 959.Google Scholar