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Russian Journal of Bioorganic Chemistry

, Volume 45, Issue 6, pp 585–590 | Cite as

Synthesis and Biological Evaluation of Novel Steroidal 5α,8α-Endoperoxide Derivatives with Aromatic Hydrazone Side Chain as Potential Anticancer Agents

  • H. J. Wang
  • M. BuEmail author
  • J. Wang
  • L. Liu
  • S. Zhang
Article
  • 4 Downloads

Abstract

Seven new steroidal 5α,8α-endoperoxide derivatives with C-17 aromatic hydrazone side chain were synthesized. Structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectrometry. Anti-proliferative activities of the synthesized compounds were evaluated in vitro by the MTT method. Among the seven compounds, 5α,8α-epidioxy-17-(4-chloro-benzylidene)-hydrazonoandrost-3β-ol showed the strongest anti-proliferative activity against three human cancer cell lines (MCF-7, HepG2, and SK-Hep1).

Keywords:

steroid ergosterol peroxide dehydroepiandrosterone dihydrazone antitumor activity 

Notes

FUNDING

This study was supported by Qiqihar Academy of Medical Sciences Project (QMSI 2017B-09).

COMPLIANCE WITH ETHICAL STANDARDS

The work has no studies involving humans or animals as subjects of the study.

Conflict of Interests

Authors declare that they have no conflicts of interests.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.College of Pharmacy, Qiqihar Medical UniversityQiqiharChina
  2. 2.Basic Medical Science College, Qiqihar Medical UniversityQiqiharChina

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