Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells
Targeted cationic liposomes containing folate lipoconjugates with spacer groups of various lengths and natures were prepared; their physicochemical characteristics and their transfection activity towards KB-3-1 and HEK 293 cells were determined. Targeted delivery of plasmid DNA was studied by competitive inhibition of DNA delivery in the presence of free folic acid.
Keywords:cationic liposomes targeted delivery folate-containing lipoconjugates folic acid transfection nucleic acids
The work was financially supported by the Russian Science Foundation (project no. 18-73-00270).
COMPLIANCE WITH ETHICAL STANDARDS
This article does not contain any studies involving animals or human participants performed by any of the authors.
Conflict of interests.
The authors declare that they have no conflict of interest.
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