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Russian Journal of Bioorganic Chemistry

, Volume 45, Issue 6, pp 719–725 | Cite as

Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells

  • E. V. Shmendel
  • T. O. Kabilova
  • N. G. Morozova
  • M. A. Zenkova
  • M. A. MaslovEmail author
Article

Abstract

Targeted cationic liposomes containing folate lipoconjugates with spacer groups of various lengths and natures were prepared; their physicochemical characteristics and their transfection activity towards KB-3-1 and HEK 293 cells were determined. Targeted delivery of plasmid DNA was studied by competitive inhibition of DNA delivery in the presence of free folic acid.

Keywords:

cationic liposomes targeted delivery folate-containing lipoconjugates folic acid transfection nucleic acids 

Notes

FUNDING

The work was financially supported by the Russian Science Foundation (project no. 18-73-00270).

COMPLIANCE WITH ETHICAL STANDARDS

This article does not contain any studies involving animals or human participants performed by any of the authors.

Conflict of interests.

The authors declare that they have no conflict of interest.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • E. V. Shmendel
    • 1
  • T. O. Kabilova
    • 2
  • N. G. Morozova
    • 1
  • M. A. Zenkova
    • 2
  • M. A. Maslov
    • 1
    Email author
  1. 1.Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological UniversityMoscowRussia
  2. 2.Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of SciencesNovosibirskRussia

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