Russian Journal of Bioorganic Chemistry

, Volume 44, Issue 2, pp 244–251 | Cite as

Design, Synthesis, Antioxidant and Antibacterial Activities of Novel 2-((1-Benzyl-1H-1,2,3-Triazol-4-yl)methyl)-5-(2HChromen- 3-yl)-2H-Tetrazoles

  • Burra Srinivas
  • P. Vijay Kumar
  • P. Nagendra Reddy
  • Sankeshi Venu
  • Perugu Shyam
  • G. L. David Krupadanam
Article
  • 8 Downloads

Abstract

1,4-Disubstituted 1,2,3-triazole derivatives of 2H-chromene-3-tetrazoles synthesized regioselectively by copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) click reaction were characterized by 1HNMR, 13C NMR, IR, and mass spectral data. These derivatives were screened for in vitro antioxidant activity using DPPH radical, H2O2 scavenging, and iron chelating activity methods and also evaluated for in vitro antibacterial activities against E. coli and S. aureus bacterial strains. The MIC and IC50 values for all these compounds were found to match the docking scores and relevant binding energies with the receptor active sites. These results allows one to consider the compounds as leads for a new generation of antioxidant and antibacterial agents.

Keywords

2H-chromene 1,2,3,4-tetrazoles 1,2,3-triazoles antioxidant activity antibacterial activity molecular docking studies 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • Burra Srinivas
    • 1
  • P. Vijay Kumar
    • 1
  • P. Nagendra Reddy
    • 1
  • Sankeshi Venu
    • 2
  • Perugu Shyam
    • 3
  • G. L. David Krupadanam
    • 1
  1. 1.Natural Products Lab, Department of ChemistryOsmania UniversityHyderabad, TelanganaIndia
  2. 2.Department of ZoologyOsmania UniversityHyderabad, TelanganaIndia
  3. 3.National Institute of NutritionTarnaka, Hyderabad, TelanganaIndia

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