Russian Journal of Bioorganic Chemistry

, Volume 42, Issue 2, pp 198–209 | Cite as

Synthesis of some new N-substituted-N-(2,3-Dihydro-[1,4]benzodioxin-6-yl)-4-acetamidobenzenesulfonamides as valuable antibacterial agents

  • M. A. AbbasiEmail author
  • S. Tariq
  • Aziz-ur-Rehman
  • S. Z. Siddiqui
  • I. Ahmad
  • R. Malik
  • S. A. A. Shah


The aim of the research was to investigate the anti-bacterial potential of some N-substituted sulfonamides bearing benzodioxane moiety. The synthesis was started by reaction of N-2,3-dihydrobenzo[1,4]dioxin-6-amine with 4-acetamidobenzene-1-sulfonyl chloride in the presence of 10% aqueous Na2CO3 solution to yield N-(2,3-dihydrobenzo[1,4]-dioxin-6-yl)-4-acetamidobenzenesulfonamide, which was further reacted with alkyl/aralkyl halides in DMF and lithium hydride as a base to afford N-substituted-N-(2,3dihydro-[1,4]-benzodioxin-6-yl)-4-acetamidobenzenesulfonamides. All the synthesized compounds were characterized by spectral data (IR, 1H NMR, EI-MS, and HR-MS). The compounds were tested for antibacterial activity and most of them exhibited potent therapeutic potential against various Gram-negative and Gram-positive strains.


N-(2,3-dihydrobenzo[1,4]-dioxin-6-yl)-4-acetamidobenzenesulfonamide alkyl/aralkyl halides spectral analysis antibacterial activity 


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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • M. A. Abbasi
    • 1
    Email author
  • S. Tariq
    • 1
  • Aziz-ur-Rehman
    • 1
  • S. Z. Siddiqui
    • 1
  • I. Ahmad
    • 2
  • R. Malik
    • 2
  • S. A. A. Shah
    • 3
    • 4
  1. 1.Department of ChemistryGovernment College UniversityLahorePakistan
  2. 2.Department of Pharmacythe Islamia University of BahawalpurBahawalpurPakistan
  3. 3.Faculty of PharmacyUniversity Technology MARA, Puncak Alam Campus42300Bandar Puncak Alam, Selangor Darul EhsanMalaysia
  4. 4.Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Level 9, FF3University Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak AlamSelangor Darul EhsanMalaysia

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