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Russian Journal of Bioorganic Chemistry

, Volume 40, Issue 3, pp 343–349 | Cite as

A green synthetic approach to the synthesis of Schiff bases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile as potential anti-inflammatory agents

  • Sh. A. Abdel-Mohsen
  • E. M. Hussein
Article

Abstract

A green, novel, rapid, and efficient protocol is developed for the synthesis of various Schiff bases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile using ammonium chloride as a very inexpensive and readily available reagent in refluxing ethanol. High yields, easy work-up, and short reaction times are advantages of this environmentally benign procedure. The prepared compounds were screened for their anti-inflammatory activity “at a dose of 10 mg/kg body weight,” which revealed promising activities relative to indomethacin used as a reference standard in this study.

Keywords

green synthesis Schiff bases anti-inflammatory rapid procedure 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile 

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceAssiut UniversityAssiutEgypt

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