Russian Journal of Bioorganic Chemistry

, Volume 38, Issue 6, pp 565–577 | Cite as

Recombinant diphtheria toxin derivatives: Perspectives of application

  • S. I. Romaniuk
  • D. V. Kolybo
  • S. V. Komisarenko
Article

Abstract

Diphtheria toxin (DT) is a unique bacterial protein which consists of three domains with various biological functions. Using genetic engineering for the creation of various recombinant constructions of DT with definite features, it is possible to create unique tools for cellular biology and toxins with efficient and selective action on certain populations of cells. The review highlights the structural and functional aspects of the DT molecule, its fragments and domains, as well as the major areas of application of its recombinant derivatives. In particular, the perspectives for practical use of recombinant DT derivatives are discussed for creating immunobiological preparations, cytotoxins, blockers of the heparin-binding epidermal growth factor-like growth factor (HB-EGF), protein constructions for direct delivery of substances into the cell, and also the possibility to use DT recombinant derivatives for therapy and prevention of a number of diseases.

Keywords

diphtheria toxin fragments and domains of diphtheria toxin recombinant proteins heparin-binding epidermal growth factor-like growth factor (HB-EGF) vaccines cytotoxins 

Abbreviations

DT

diphtheria toxin

CRM

cross-reacting material (mutant diphtheria toxoid is similar in its antigenic features to the diphtheria toxin)

HB-EGF

heparin-binding epidermal growth factor-like growth factor

IL

interleukin

scFv

a single-chain fragment variable

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • S. I. Romaniuk
    • 1
  • D. V. Kolybo
    • 1
  • S. V. Komisarenko
    • 1
  1. 1.Palladin Institute of BiochemistryNational Academy of Sciences of UkraineKyivUkraine

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