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Russian Journal of Bioorganic Chemistry

, Volume 36, Issue 6, pp 684–689 | Cite as

Biological functions of MicroRNAs

  • Yong Huang
  • Xing Jia ShenEmail author
  • Quan Zou
  • Qiao Ling Zhao
Article

Abstract

The small regulatory non-coding RNA molecules, known as microRNAs (miRNAs), have been recognized as potential regulator of gene expression and modulate the gene function at the post-transcriptional level. It is now clear that miRNA biogenesis and function are related to the molecular mechanisms of various clinical diseases, which can potentially regulate every aspect of cellular activity, including differentiation and development, metabolism, proliferation, apoptotic cell death viral infection and tumorgenesis. Here, we review recent work and provide insight into the diverse roles of miRNAs.

Keywords

microRNA biogenesis function expression diseases 

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • Yong Huang
    • 1
  • Xing Jia Shen
    • 1
    • 2
    Email author
  • Quan Zou
    • 3
  • Qiao Ling Zhao
    • 1
    • 2
  1. 1.Jiang Su University of Science and TechnologyZhenjiang CityJiangsu Province, PR China
  2. 2.The Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research InstituteChinese Academy of Agricultural SciencesZhenjiang CityJiangsu Province, PR China
  3. 3.School of Information Science and Technology of Xiamen UniversityXiamen CityFujian Province, PR China

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