Russian Journal of Bioorganic Chemistry

, Volume 36, Issue 6, pp 684–689 | Cite as

Biological functions of MicroRNAs

  • Yong Huang
  • Xing Jia ShenEmail author
  • Quan Zou
  • Qiao Ling Zhao


The small regulatory non-coding RNA molecules, known as microRNAs (miRNAs), have been recognized as potential regulator of gene expression and modulate the gene function at the post-transcriptional level. It is now clear that miRNA biogenesis and function are related to the molecular mechanisms of various clinical diseases, which can potentially regulate every aspect of cellular activity, including differentiation and development, metabolism, proliferation, apoptotic cell death viral infection and tumorgenesis. Here, we review recent work and provide insight into the diverse roles of miRNAs.


microRNA biogenesis function expression diseases 


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  1. 1.
    Guarnieri, D.J. and DiLeone, R.J., Ann Med., 2008, vol. 2, pp. 197–208.CrossRefGoogle Scholar
  2. 2.
    Bartel, D.P., Cell, 2009, vol. 136, pp. 215–233.CrossRefPubMedGoogle Scholar
  3. 3.
    Lee, R.C., Feinbaum, R.L., and Ambros, V., Cell, 1993, vol. 75, pp. 843–854.CrossRefPubMedGoogle Scholar
  4. 4.
    Wightman, B., Ha, I., and Ruvkun, G., Cell, 1993, vol. 75, pp. 855–862.CrossRefPubMedGoogle Scholar
  5. 5.
    Olsen, P.H., and Ambros, V., Dev. Biol., 1999, vol. 216, pp. 671–680.CrossRefPubMedGoogle Scholar
  6. 6.
    Reinhart, B.J., Slack, F.J., Basson, M., Pasquinelli, A.E., Bettinger, J.C., Rougvie, A.E., Horvitz, H.R., and Ruvkun, G., Nature, 2000, vol. 403, pp. 901–906.CrossRefPubMedGoogle Scholar
  7. 7.
    Krek, A., Grun, D., Poy, M.N., Wolf, R., Rosenberg, L., Epstein, E.J., MacMenamin, P., da Piedade, I., Gunsalus, K.C., Stoffel, M., and Rajewsky, N., Nat. Genet., 2005, vol. 37, pp. 495–500.CrossRefPubMedGoogle Scholar
  8. 8.
    Seitz, H. and Zamore, P.D., Cell, 2006, vol. 125, pp. 827–829.CrossRefPubMedGoogle Scholar
  9. 9.
    Liu, X., Luo, G., Bai, X., and Wang, X.J.J., Genet. Genomics., 2009, vol. 36, pp. 591–601.CrossRefGoogle Scholar
  10. 10.
    Du, T. and Zamore, P.D., Development, 2005, vol. 132, pp. 4645–4652.CrossRefPubMedGoogle Scholar
  11. 11.
    Papp, I., Mette, M.F., Aufsatz, W., Daxinger, L., Schauer, S.E., Ray, A., van der Winden, J., Matzke, M., and Matzke, A.J., Plant Physiol., 2003, vol. 132, pp. 1382–1390.CrossRefPubMedGoogle Scholar
  12. 12.
    Shomron, N. and Levy, C., J. Biomed. Biotechnol., 2009, vol. 2009, pp. 594–678.Google Scholar
  13. 13.
    Park, W., Li, J., Song, R., Messing, J., and Chen, X., Curr. Biol., 2002, vol. 12, pp. 1484–1495.CrossRefPubMedGoogle Scholar
  14. 14.
    Schratt, G.M., Tuebing, F., Nigh, E.A., Kane, C.G., Sabatini, M.E., Kiebler, M., and Greenberg, M.E., Nature, 2006, vol. 439, pp. 283–289.CrossRefPubMedGoogle Scholar
  15. 15.
    Kim, J., Inoue, K., Ishii, J., Vanti, W.B., Voronov, S.V., Murchison, E., Hannon, G., and Abeliovich, A., Science., 2007, vol. 317, pp. 1220–1224.CrossRefPubMedGoogle Scholar
  16. 16.
    Sempere, L.F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., and Ambros, V., Genome Biol., 2004, vol. 5, p. R13.Google Scholar
  17. 17.
    Smirnova, L., Grafe, A., Seiler, A., Schumacher, S., Nitsch, R., and Wulczyn, F.G., Eur. J. Neurosci., 2005, vol. 21, pp. 1469–1477.CrossRefPubMedGoogle Scholar
  18. 18.
    Song, L. and Tuan, R.S., Birth. Defects Res. C Embryo Today, 2006, vol. 78, pp. 140–149.CrossRefPubMedGoogle Scholar
  19. 19.
    Chen, C.Z., Li, L., Lodish, H.F., and Bartel, D.P., Science, 2004, vol. 303, pp. 83–86.CrossRefPubMedGoogle Scholar
  20. 20.
    Johnston, R.J., Hobert, O., Nature, 2003, vol. 426, pp. 845–849.CrossRefPubMedGoogle Scholar
  21. 21.
    Bushati, N. and Cohen, S.M., Annu. Rev. Cell Dev. Biol., 2007, vol. 23, pp. 175–205.CrossRefPubMedGoogle Scholar
  22. 22.
    Johnston, R.J.J., Chang, S., Etchberger, J.F., Ortiz, C.O., and Hobert, O., Proc. Natl. Acad. Sci. USA, 2005, vol. 102, pp. 1249–1254.CrossRefGoogle Scholar
  23. 23.
    Visvanathan, J., Lee, S., Lee, B., Lee, J.W., and Lee, S.K., Genes Dev., 2007, vol, 21, pp. 744–749.CrossRefPubMedGoogle Scholar
  24. 24.
    Coulson, J.M., Curr. Biol., 2005, vol. 15, pp. R665–668.CrossRefPubMedGoogle Scholar
  25. 25.
    Shi, Y. and Jin, Y., Sci. China C Life Sci., 2009, vol. 52, pp. 205–211.CrossRefPubMedGoogle Scholar
  26. 26.
    Makeyev, E.V., Zhang, J., Carrasco, M.A., and Maniatis, T., Mol. Cell, 2007, vol. 27, pp. 435–448.CrossRefPubMedGoogle Scholar
  27. 27.
    Melton, C., Judson, R.L., and Blelloch, R., Nature, 2010, vol. 463, pp. 621–626.CrossRefPubMedGoogle Scholar
  28. 28.
    Sugatani, T. and Hruska, K.A., J. Biol. Chem., 2009, vol. 284, pp. 4667–4678.CrossRefPubMedGoogle Scholar
  29. 29.
    Zhang, Y., Chao, T., Li, R., Liu, W., Chen, Y., Yan, X., Gong, Y., Yin, B., Qiang, B., Zhao, J., Yuan, J., and Peng, X., J. Mol. Med., 2009, vol. 87, pp. 43–51.CrossRefPubMedGoogle Scholar
  30. 30.
    Ivey, K.N., Muth, A., Arnold, J., King, F.W., Yeh, R.F., Fish, J.E., Hsiao, E.C., Schwartz, R.J., Conklin, B.R., Bernstein, H.S., et al., Cell Stem. Cell, 2008, vol. 2, pp. 219–229.CrossRefPubMedGoogle Scholar
  31. 31.
    Kiyosawa, K., Sodeyama, T., Tanaka, E., Gibo, Y., Yoshizawa, K., Nakano, Y., Furuta, S., Akahane, Y., Nishioka, K., Purcell, R.H., et al., Hepatology, 1990, vol. 12, pp. 671–675.CrossRefPubMedGoogle Scholar
  32. 32.
    Jin, W.B., Wu, F.L., Kong, D., and Guo, A.G., Comput. Biol. Chem., 2007, vol. 31, pp. 124–126.CrossRefPubMedGoogle Scholar
  33. 33.
    Jopling, C.L., Yi, M., Lancaster, A.M., Lemon, S.M., and Sarnow, P., Science, 2005, vol. 309, pp. 1577–1581.CrossRefPubMedGoogle Scholar
  34. 34.
    Pedersen, I.M., Cheng, G., Wieland, S., Volinia, S., Croce, C.M., Chisari, F.V., and David, M., Nature, 2007, vol. 449, pp. 919–922.CrossRefPubMedGoogle Scholar
  35. 35.
    Sonkoly, E., Wei, T., Janson, P.C., Saaf, A., Lundeberg, L., Tengvall-Linder, M., Norstedt, G., Alenius, H., Homey, B., Scheynius, A., Stahle, M., and Pivarcsi, A., PLoS One, 2007, vol. 2, pp. e610.CrossRefPubMedGoogle Scholar
  36. 36.
    Chen, T., Huang, Z., Wang, L., Wang, Y., Wu, F., Meng, S., and Wang, C,. Cardiovasc. Res., 2009. vol. 83, p. 131–139.CrossRefPubMedGoogle Scholar
  37. 37.
    Wang, S., Aurora, A.B., Johnson, B.A., Qi, X., McAnally, J., Hill, J.A., Richardson, J.A., Bassel-Duby, R., and Olson, E.N., Dev. Cell, 2008, vol. 15, pp. 261–271.CrossRefPubMedGoogle Scholar
  38. 38.
    O’Connell, R.M., Rao, D.S., Chaudhuri, A.A., Boldin, M.P., Taganov, K.D., Nicoll, J., Paquette, R.L., and Baltimore, D., J. Exp. Med., 2008, vol. 205, pp. 585–594.CrossRefPubMedGoogle Scholar
  39. 39.
    Cordes, K.R., Sheehy, N.T., White, M.P., Berry, E.C., Morton, S.U., Muth, A.N., Lee, T.H., Miano, J.M., Ivey, K.N., and Srivastava, D., Nature, 2009, vol. 460, pp. 705–710.PubMedGoogle Scholar
  40. 40.
    Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., and Tuschl, T., Curr. Biol., 2002, vol. 12, pp. 735–739.CrossRefPubMedGoogle Scholar
  41. 41.
    Chan, J.A., Krichevsky, A.M., and Kosik, K.S., Cancer Res., 2005, vol. 65, pp. 6029–6033.CrossRefPubMedGoogle Scholar
  42. 42.
    Ciafre, S.A., Galardi, S., Mangiola, A., Ferracin, M., Liu, C.G., Sabatino, G., Negrini, M., Maira, G., Croce, C.M., and Farace, M.G., Biochem. Biophys. Res. Commun., 2005, vol. 334, pp. 1351–1358.CrossRefPubMedGoogle Scholar
  43. 43.
    Kim, H.J., Kim, Y.H., Lee, D.S., Chung, J.K., and Kim, S., J. Nucl. Med., 2008, vol. 49, pp. 1686–1693.CrossRefPubMedGoogle Scholar
  44. 44.
    Takamizawa, J., Konishi, H., Yanagisawa, K., Tomida, S., Osada, H., Endoh, H., Harano, T., Yatabe, Y., Nagino, M., Nimura, Y., Mitsudomi, T., and Takahashi, T., Cancer Res., 2004, vol. 64, pp. 3753–3756.CrossRefPubMedGoogle Scholar
  45. 45.
    Wurdinger, T., Tannous, B.A., Saydam, O., Skog, J., Grau, S., Soutschek, J., Weissleder, R., Breakefield, X.O., and Krichevsky, A.M., Cancer Cell, 2008, vol. 14, pp. 382–393.CrossRefPubMedGoogle Scholar
  46. 46.
    El Ouaamari, A., Baroukh, N., Martens, G.A., Lebrun, P., Pipeleers, D., and van Obberghen, E., Diabetes, 2008, vol. 57, pp. 2708–2717.CrossRefPubMedGoogle Scholar
  47. 47.
    Wang, S., Aurora, A.B., Johnson, B.A., Qi, X., McAnally, J., Hill, J.A., Richardson, J.A., Bassel-Duby, R., and Olson, E.N., Dev. Cell, 2008, vol. 15, pp. 261–271.CrossRefPubMedGoogle Scholar
  48. 48.
    O’Connell, R.M., Taganov, K.D., Boldin, M.P., Cheng, G., and Baltimore, D., Proc. Natl. Acad. Sci. USA, 2007, vol. 104, pp. 1604–1609.CrossRefPubMedGoogle Scholar
  49. 49.
    Isken, F., Steffen, B., Merk, S., Dugas, M., Markus, B., Tidow, N., Zuhlsdorf, M., Illmer, T., Thiede, C., Berdel, W.E., Serve, H., and Muller-Tidow, C. Br., J. Haematol., 2008, vol. 140, pp. 153–161.CrossRefGoogle Scholar
  50. 50.
    Carlsbecker, A., Lee, J.Y., Roberts, C.J., Dettmer, J., Lehesranta, S., Zhou, J., Lindgren, O., Moreno-Risueno, M.A., Vaten, A., Thitamadee, S., Campilho, A., Sebastian, J., Bowman, J.L., Helariutta, Y., and Benfey, P.N., Nature, 2010, doi:10.1038/nature08977.Google Scholar
  51. 51.
    Tay, Y., Zhang, J., Thomson, A.M., Lim, B., and Rigoutsos, I., Nature, 2008, vol. 455, pp. 1124–1128.CrossRefPubMedGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • Yong Huang
    • 1
  • Xing Jia Shen
    • 1
    • 2
    Email author
  • Quan Zou
    • 3
  • Qiao Ling Zhao
    • 1
    • 2
  1. 1.Jiang Su University of Science and TechnologyZhenjiang CityJiangsu Province, PR China
  2. 2.The Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research InstituteChinese Academy of Agricultural SciencesZhenjiang CityJiangsu Province, PR China
  3. 3.School of Information Science and Technology of Xiamen UniversityXiamen CityFujian Province, PR China

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