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Russian Journal of Bioorganic Chemistry

, Volume 34, Issue 1, pp 118–124 | Cite as

Polyhydroxylated steroid compounds from the Far Eastern starfish Distolasterias nipon

  • A. A. KichaEmail author
  • I. I. Kapustina
  • N. V. Ivanchina
  • A. I. Kalinovsky
  • P. S. Dmitrenok
  • V. A. Stonik
  • N. V. Pal’yanova
  • T. M. Pankova
  • M. V. Starostina
Article

Abstract

Two new steroid glycosides: distolasteroside D6, (24S)-24-O-(β-D-xylopyranosyl)-5α-cholestane-3β,6α,8,15β,16β,24-hexaol, and distolasteroside D7, (22E,24R)-24-O-(β-D-xylopyranosyl)-5α-cholest-22-ene-3β,6α,8,15β,24-pentaol were isolated along with the previously known distolasterosides D1, D2, and D3, echinasteroside C, and (25S)-5α-cholestane-3β4β,6α,7α,8,15α,16β,26-octaol from the Far Eastern starfish Distolasterias nipon. The structures of new compounds were elucidated by NMR spectroscopy and MALDI TOF mass spectrometry. Like neurotrophins, distolasterosides D1, D2, and D3 were shown to induce neuroblast differentiation in a mouse neuroblastoma C1300 cell culture.

Key words

differentiation Distolasterias nipon glycosides neuroblastoma polyhydroxysteroids starfish 

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Copyright information

© Pleiades Publishing, Ltd. 2008

Authors and Affiliations

  • A. A. Kicha
    • 1
    Email author
  • I. I. Kapustina
    • 1
  • N. V. Ivanchina
    • 1
  • A. I. Kalinovsky
    • 1
  • P. S. Dmitrenok
    • 1
  • V. A. Stonik
    • 1
  • N. V. Pal’yanova
    • 2
  • T. M. Pankova
    • 2
  • M. V. Starostina
    • 2
  1. 1.Pacific Institute of Bioorganic Chemistry, Far East DivisionRussian Academy of SciencesVladivostokRussia
  2. 2.Institute of Molecular Biology and Biophysics, Siberian BranchRussian Academy of Medical SciencesNovosibirskRussia

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