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Russian Journal of Bioorganic Chemistry

, Volume 32, Issue 3, pp 261–276 | Cite as

Biological activity and pharmacological prospects of lupane terpenoids: II. Semisynthetic lupane derivatives

  • T. G. Tolstikova
  • I. V. Sorokina
  • G. A. Tolstikov
  • A. G. Tolstikov
  • O. B. Flekhter
Review Articles

Abstract

The discussion of lupane triterpenoids as prospective medicinal preparations is continued, and semisynthetic triterpenoids are being discussed. Acyl derivatives that mainly exhibit high anti-HIV, antitumor, and organoprotective activities are described.

Key words

anti-HIV activity betulin betulinic acid betulonic acid cytostatic and organoprotective activities 

Abbreviations

BA

betulinic acid

EC

effective concentration

TI

therapeutic index

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Copyright information

© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  • T. G. Tolstikova
    • 1
  • I. V. Sorokina
    • 1
  • G. A. Tolstikov
    • 1
  • A. G. Tolstikov
    • 2
  • O. B. Flekhter
    • 3
  1. 1.Vorozhtsov Institute of Organic Chemistry, Novosibirsk, Siberian DivisionRussian Academy of SciencesNovosibirskRussia
  2. 2.Institute of Technical Chemistry, Ural DivisionRussian Academy of SciencesPermRussia
  3. 3.Institute of Organic Chemistry, Ufa Scientific CenterRussian Academy of SciencesUfaRussia

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