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Russian Journal of Bioorganic Chemistry

, Volume 32, Issue 1, pp 37–49 | Cite as

Biological activity and pharmacological prospects of lupane terpenoids: I. natural lupane derivatives

  • T. G. Tolstikova
  • I. V. Sorokina
  • G. A. Tolstikov
  • A. G. Tolstikov
  • O. B. Flekhter
Review Articles

Abstract

The biological activity of natural and semisynthetic lupane triterpenoids is discussed in a two-part review. The first part is devoted to the pharmacological properties of natural lupane triterpenoids. Betulinic acid has proven to be the most effective antitumor agent among more than fifty natural lupanes.

Key words

anti-HIV activity betulin betulinic acid betulonic acid 

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Copyright information

© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  • T. G. Tolstikova
    • 1
  • I. V. Sorokina
    • 1
  • G. A. Tolstikov
    • 1
  • A. G. Tolstikov
    • 2
  • O. B. Flekhter
    • 3
  1. 1.Vorozhtsov Institute of Organic Chemistry, Novosibirsk, Siberian DivisionRussian Academy of SciencesNovosibirskRussia
  2. 2.Institute of Technical Chemistry, Ural DivisionRussian Academy of SciencesPermRussia
  3. 3.Institute of Organic Chemistry, Ufa Scientific CenterRussian Academy of SciencesUfaRussia

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